High‐dose vs low‐dose colchicine
Total adverse events · acute gout
High‐dose may leads to higher total adverse events compared with low‐dose colchicine (low certainty).
1 finding from 1 review
- RR 2.11 [1.51, 2.95]1 study · 126 participantsLow
Findings
What do systematic reviews say?
4 questions · 5 findings · 3 reviews · Headline outcomes only
No studies found 0 · 0%GRADE not reported 2 · 40%Very low 0 · 0%Low 3 · 60%Moderate 0 · 0%High 0 · 0%
High‐dose colchicine vs placebo
Total adverse events · acute gout
High‐dose colchicine may leads to higher total adverse events compared with placebo (low certainty).
1 finding from 1 review
- RR 3.21 [2.01, 5.11]2 studies · 124 participantsLow
High‐dose methylphenidate vs placebo
Total number of adverse events · Children aged 6 to 18 years with ASD
2 findings from 1 review
- Methylphenidate for children and adolescents with autism spectrum disorder 2017 · Cochrane Headline outcomes onlyno estimate extracted1 study · 108 participantsGRADE not reported
- Methylphenidate for children and adolescents with autism spectrum disorder 2017 · Cochrane Headline outcomes onlyno estimate extracted1 study · 79 participantsGRADE not reported
Lower blood pressure targets vs standard blood pressure targets
Total serious adverse events · cardiovascular disease with high blood pressure
Lower blood pressure targets showed no clear difference in total serious adverse events compared with standard blood pressure targets (low certainty).
1 finding from 1 review
- Blood pressure targets for the treatment of people with hypertension and cardiovascular disease 2022 · Cochrane Headline outcomes onlyRR 1.01 [0.94, 1.08]7 studies · 9595 participantsLow