Findings

What do systematic reviews say?

2 questions · 2 findings · 2 reviews · Epilepsy

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No studies found 0 · 0%GRADE not reported 0 · 0%Very low 0 · 0%Low 1 · 50%Moderate 1 · 50%High 0 · 0%

Sodium valproate vs phenytoin monotherapy

Time to first seizure (post‐randomisation) Subgroup: focal onset seizures Range of · adults and children with newly‐onset focal onset or generalised tonic‐clonic seizures

Sodium valproate showed no clear difference in time to first seizure (post‐randomisation) Subgroup: focal onset… compared with phenytoin monotherapy (low certainty).

1 finding from 1 review

Sodium valproate versus phenytoin monotherapy for epilepsy: an individual participant data review 2018 · Cochrane Headline outcomes only
HR 1.2 [0.9, 1.6]
4 studies · 244 participants
Low

Carbamazepine vs phenobarbitone

Time to first seizure (post‐randomisation) Subgroup: focal onset seizures Range of · adults and children with newly onset partial or generalised epilepsy

Carbamazepine probably leads to higher time to first seizure (post‐randomisation) Subgroup: focal onset… compared with phenobarbitone (moderate certainty).

1 finding from 1 review

Carbamazepine versus phenobarbitone monotherapy for epilepsy: an individual participant data review 2018 · Cochrane Headline outcomes only
HR 1.31 [1.04, 1.66]
6 studies · 584 participants
Moderate