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Evidence found and GRADE certainty

3 questions · 3 findings · 3 reviews · Epilepsy

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No studies found 0 · 0%GRADE not reported 0 · 0%Very low 0 · 0%Low 1 · 33.3%Moderate 2 · 66.7%High 0 · 0%

Sodium valproate vs phenytoin monotherapy

Time to first seizure (post‐randomisation) Subgroup: focal onset seizures Range of · adults and children with newly‐onset focal onset or generalised tonic‐clonic seizures

Sodium valproate showed no clear difference in time to first seizure (post‐randomisation) Subgroup: focal onset… compared with phenytoin monotherapy (low certainty).

1 finding from 1 review

Carbamazepine vs phenobarbitone

Time to first seizure (post‐randomisation) Subgroup: focal onset seizures Range of · adults and children with newly onset partial or generalised epilepsy

Carbamazepine probably leads to higher time to first seizure (post‐randomisation) Subgroup: focal onset… compared with phenobarbitone (moderate certainty).

1 finding from 1 review

Oxcarbazepine vs phenytoin

Time to first seizure (post‐randomisation) Subgroup: focal onset seizures Range of · people with newly diagnosed epilepsy

Summary of findings: oxcarbazepine showed no clear difference in time to first seizure (post‐randomisation) Subgroup: focal onset… compared with phenytoin (secondary outcomes) (moderate certainty).

1 finding from 1 review