Findings

What do systematic reviews say?

3 questions · 3 findings · 3 reviews · Epilepsy

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No studies found 0 · 0%GRADE not reported 0 · 0%Very low 0 · 0%Low 1 · 33.3%Moderate 2 · 66.7%High 0 · 0%

Sodium valproate vs phenytoin monotherapy

Time to first seizure (post‐randomisation) All participants Range of · adults and children with newly‐onset focal onset or generalised tonic‐clonic seizures

Sodium valproate showed no clear difference in time to first seizure (post‐randomisation) All participants Range of compared with phenytoin monotherapy (low certainty).

1 finding from 1 review

Sodium valproate versus phenytoin monotherapy for epilepsy: an individual participant data review 2018 · Cochrane Headline outcomes only
HR 1.08 [0.88, 1.33]
5 studies · 639 participants
Low

Carbamazepine vs phenobarbitone

Time to first seizure (post‐randomisation) All participants Range of · adults and children with newly onset partial or generalised epilepsy

Carbamazepine showed no clear difference in time to first seizure (post‐randomisation) All participants Range of compared with phenobarbitone (moderate certainty).

1 finding from 1 review

Carbamazepine versus phenobarbitone monotherapy for epilepsy: an individual participant data review 2018 · Cochrane Headline outcomes only
HR 1.13 [0.93, 1.38]
6 studies · 822 participants
Moderate

Oxcarbazepine vs phenytoin

Time to first seizure (post‐randomisation) All participants Range of · people with newly diagnosed epilepsy

Summary of findings: oxcarbazepine showed no clear difference in time to first seizure (post‐randomisation) All participants Range of compared with phenytoin (secondary outcomes) (moderate certainty).

1 finding from 1 review

Oxcarbazepine versus phenytoin monotherapy for epilepsy: an individual participant data review 2018 · Cochrane Headline outcomes only
HR 0.97 [0.75, 1.26]
2 studies · 468 participants
Moderate