Oral creatine vs placeboTime from beginning of treatment until death or full‐time ventilation · children with SMA types II and III1 finding from 1 reviewDrug treatment for spinal muscular atrophy types II and III 2020 · Cochrane Headline outcomes onlyno estimate extracted1 study · 40 participantsModerate
Oral olesoxime vs placeboTime from beginning of treatment until death or full‐time ventilation · non‐ambulatory children and adolescents with SMA types II and III1 finding from 1 reviewDrug treatment for spinal muscular atrophy types II and III 2020 · Cochrane Headline outcomes onlyno estimate extracted1 study · 160 participantsModerate
Oral hydroxyurea vs placeboTime from beginning of treatment until death or full‐time ventilation · children and adults with SMA types II and III1 finding from 1 reviewDrug treatment for spinal muscular atrophy types II and III 2020 · Cochrane Headline outcomes onlyno estimate extracted1 study · 57 participantsModerate
Oral valproic acid vs placeboTime from beginning of treatment until death or full‐time ventilation · ambulatory adults with SMA type III1 finding from 1 reviewDrug treatment for spinal muscular atrophy types II and III 2020 · Cochrane Headline outcomes onlyno estimate extracted33 participantsLow
Oral phenylbutyrate vs placeboTime from beginning of treatment until death or full‐time ventilation · children with SMA type II1 finding from 1 reviewDrug treatment for spinal muscular atrophy types II and III 2020 · Cochrane Headline outcomes onlyno estimate extracted1 study · 107 participantsLow
Oral valproic acid plus acetyl‐L‐carnitine vs placeboTime from beginning of treatment until death or full‐time ventilation · non‐ambulatory children with SMA types II and III1 finding from 1 reviewDrug treatment for spinal muscular atrophy types II and III 2020 · Cochrane Headline outcomes onlyno estimate extracted1 study · 61 participantsModerate