Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

21 questions · 21 findings · 3 reviews

No studies found 0 · 0%GRADE not reported 0 · 0%Very low 18 · 85.7%Low 1 · 4.8%Moderate 2 · 9.5%High 0 · 0%

Heparin prophylaxis vs no treatment/placebo

Symptomatic PE · pregnant women at increased risk of VTE during pregnancy and the early postnatal period

It is very uncertain whether antenatal (± postnatal) prophylaxis: heparin (LMWH or UFH) changes symptomatic PE ( compared with no treatment/placebo (very low certainty).

1 finding from 1 review

Heparin prophylaxis vs no treatment/placebo

Symptomatic DVT · pregnant women at increased risk of VTE during pregnancy and the early postnatal period

It is very uncertain whether antenatal (± postnatal) prophylaxis: heparin (LMWH or UFH) changes symptomatic DVT ( compared with no treatment/placebo (very low certainty).

1 finding from 1 review

LMWH prophylaxis vs UFH

Symptomatic thromboembolic events ( · pregnant women at increased risk of VTE during pregnancy and the early postnatal period

It is very uncertain whether antenatal (± postnatal) prophylaxis: LMWH changes symptomatic thromboembolic events ( compared with UFH (very low certainty).

1 finding from 1 review

Heparin prophylaxis vs no treatment/placebo

Symptomatic thromboembolic events ( · pregnant women at increased risk of VTE during pregnancy and the early postnatal period

It is very uncertain whether antenatal (± postnatal) prophylaxis: heparin (LMWH or UFH) changes symptomatic thromboembolic events ( compared with no treatment/placebo (very low certainty).

1 finding from 1 review

Peripartum/postnatal prophylaxis (caesarean): LMWH vs UFH

Symptomatic DVT · women giving birth by elective or emergency caesarean (elective or emergency (1 trial), elective cesarean only (1 trial),…

It is very uncertain whether peripartum/postnatal prophylaxis (caesarean): LMWH changes symptomatic DVT (timing of assessment unclear, within 6 weeks… compared with UFH (very low certainty).

1 finding from 1 review

Peripartum/postnatal prophylaxis (caesarean): LMWH vs UFH

Symptomatic thromboembolic events ( · women giving birth by elective or emergency caesarean (elective or emergency (1 trial), elective cesarean only (1 trial),…

It is very uncertain whether peripartum/postnatal prophylaxis (caesarean): LMWH changes symptomatic thromboembolic events (timing of assessment unclear,… compared with UFH (very low certainty).

1 finding from 1 review

Peripartum/postnatal prophylaxis (caesarean): heparin (LMWH or UFH) vs no treatment/placebo

Symptomatic PE · women giving birth by elective or emergency caesarean (elective only (1 trial), emergency or elective (4 trials))

It is very uncertain whether peripartum/postnatal prophylaxis (caesarean): heparin (LMWH or UFH) changes symptomatic PE (timing of assessment unclear, within 6 weeks… compared with no treatment/placebo (very low certainty).

1 finding from 1 review

Peripartum/postnatal prophylaxis (caesarean): heparin (LMWH or UFH) vs no treatment/placebo

Symptomatic thromboembolic events ( · women giving birth by elective or emergency caesarean (elective only (1 trial), emergency or elective (4 trials))

It is very uncertain whether peripartum/postnatal prophylaxis (caesarean): heparin (LMWH or UFH) changes symptomatic thromboembolic events (timing of assessment unclear,… compared with no treatment/placebo (very low certainty).

1 finding from 1 review

Low molecular weight heparin vs no LMWH

Symptomatic catheter‐related thrombosis (up to 3 months) · people with cancer with thrombosis prophylaxis and central venous catheters

Low‐molecular‐weight heparin (LMWH) probably leads to lower symptomatic catheter‐related thrombosis (up to 3 months) compared with no LMWH (moderate certainty).

1 finding from 1 review

Low molecular weight heparin vs no LMWH

Symptomatic catheter‐related thrombosis measured as asymptomatic catheter‐related thrombosis (up to 3 months) · people with cancer with thrombosis prophylaxis and central venous catheters

It is very uncertain whether low‐molecular‐weight heparin (LMWH) changes symptomatic catheter‐related thrombosis measured as asymptomatic… compared with no LMWH (very low certainty).

1 finding from 1 review

Low molecular weight heparin vs vitamin K antagonist (VKA)

Symptomatic catheter‐related thrombosis (up to 3 months) · people with cancer with thrombosis prophylaxis and central venous catheters

It is very uncertain whether low‐molecular‐weight heparin (LMWH) changes symptomatic catheter‐related thrombosis (up to 3 months) compared with vitamin K antagonist (VKA) (very low certainty).

1 finding from 1 review