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What do systematic reviews say?

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Evidence found and GRADE certainty

7 questions · 7 findings · 2 reviews · Childhood Cancer

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No studies found 5 · 71.4%GRADE not reported 0 · 0%Very low 0 · 0%Low 2 · 28.6%Moderate 0 · 0%High 0 · 0%

Sodium thiosulfate vs no otoprotective intervention

Overall survival with intravenous platinum (i.e. mortality/number of participants deceased) · children with cancer treated with platinum‐based therapy

Sodium thiosulfate showed no clear difference in overall survival with intravenous platinum (i.e. mortality/number of… compared with no otoprotective intervention (low certainty).

1 finding from 1 review

Sodium thiosulfate vs no otoprotective intervention

Event‐free survival · children with cancer treated with platinum‐based therapy

Sodium thiosulfate showed no clear difference in event‐free survival with intravenous platinum (i.e. number of… compared with no otoprotective intervention (low certainty).

1 finding from 1 review