Findings

What do systematic reviews say?

3 questions · 3 findings · 1 reviews

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No studies found 0 · 0%GRADE not reported 0 · 0%Very low 0 · 0%Low 1 · 33.3%Moderate 1 · 33.3%High 1 · 33.3%

Bupropion vs placebo or no pharmacological treatment

Smoking cessation · people who smoke

Bupropion leads to higher smoking cessation (at least six months of compared with placebo/no pharmacological treatment (high certainty).

1 finding from 1 review

Antidepressants for smoking cessation 2023 · Cochrane Headline outcomes only
RR 1.6 [1.49, 1.72]
50 studies · 18577 participants
High

Bupropion plus varenicline vs varenicline

Smoking cessation · people who smoke

Bupropion plus varenicline showed no clear difference in smoking cessation (at least six months of compared with varenicline alone (moderate certainty).

1 finding from 1 review

Antidepressants for smoking cessation 2023 · Cochrane Headline outcomes only
RR 1.21 [0.95, 1.55]
3 studies · 1057 participants
Moderate

Bupropion plus nicotine replacement therapy (NRT) vs NRT

Smoking cessation · people who smoke

Bupropion plus nicotine replacement therapy (NRT) showed no clear difference in smoking cessation (at least six months of compared with NRT alone (low certainty).

1 finding from 1 review

Antidepressants for smoking cessation 2023 · Cochrane Headline outcomes only
RR 1.17 [0.95, 1.44]
15 studies · 4117 participants
Low