Findings

What do systematic reviews say?

3 questions · 3 findings · 1 reviews · Metabolic and Endocrine Disorders

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No studies found 0 · 0%GRADE not reported 0 · 0%Very low 1 · 33.3%Low 1 · 33.3%Moderate 1 · 33.3%High 0 · 0%

Insulin glargine vs NPH insulin

Severe hypoglycaemia

Summary of findings: insulin glargine showed no clear difference in severe hypoglycaemia (n/N) Definition: symptomatic hypoglycaemia… compared with NPH insulin (moderate certainty).

1 finding from 1 review

(Ultra‐)long‐acting insulin analogues for people with type 1 diabetes mellitus 2021 · Cochrane Headline outcomes only
RR 0.84 [0.67, 1.04]
9 studies · 2350 participants
Moderate

Summary of findings: insulin detemir vs insulin glargine

Severe hypoglycaemia

It is very uncertain whether summary of findings: insulin detemir changes severe hypoglycaemia (n/N) Definition: hypoglycaemia requiring third… compared with insulin glargine (very low certainty).

1 finding from 1 review

(Ultra‐)long‐acting insulin analogues for people with type 1 diabetes mellitus 2021 · Cochrane Headline outcomes only
RR 0.59 [0.13, 2.63]
2 studies · 763 participants
Very low

Summary of findings: insulin degludec vs insulin glargine

Severe hypoglycaemia

Summary of findings: insulin degludec showed no clear difference in severe hypoglycaemia (n/N) Definition: hypoglycaemia requiring third… compared with insulin glargine (low certainty).

1 finding from 1 review

(Ultra‐)long‐acting insulin analogues for people with type 1 diabetes mellitus 2021 · Cochrane Headline outcomes only
RR 1.22 [0.82, 1.82]
3 studies · 970 participants
Low