Findings

What do systematic reviews say?

3 questions · 3 findings · 2 reviews

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No studies found 0 · 0%GRADE not reported 0 · 0%Very low 0 · 0%Low 2 · 66.7%Moderate 1 · 33.3%High 0 · 0%

Long‐acting beta2‐agonists vs placebo

Moderate‐to‐severe exacerbations (rate) · patients with chronic obstructive pulmonary disease

Long‐acting beta2‐agonists showed no clear difference in severe/moderate exacerbations (hospitalisation or course of… compared with placebo (moderate certainty).

1 finding from 1 review

Long‐acting beta₂‐agonists for chronic obstructive pulmonary disease 2013 · Cochrane Headline outcomes only
OR 0.88 [0.76, 1.02]
7 studies · 3968 participants
Moderate

Triple therapy vs LABA/LAMA combination

Severe exacerbations (rate) · stable COPD

Triple therapy may leads to lower severe exacerbations (rate) compared with LABA/LAMA combination (low certainty).

1 finding from 1 review

Inhaled corticosteroids with combination inhaled long‐acting beta2‐agonists and long‐acting muscarinic antagonists for… 2023 · Cochrane Headline outcomes only
RR 0.75 [0.67, 0.84]
3 studies · 14131 participants
Low

Triple therapy vs LABA/LAMA combination

Moderate‐to‐severe exacerbations (rate) · stable COPD

Triple therapy may leads to lower moderate‐to‐severe exacerbations (rate) compared with LABA/LAMA combination (low certainty).

1 finding from 1 review

Inhaled corticosteroids with combination inhaled long‐acting beta2‐agonists and long‐acting muscarinic antagonists for… 2023 · Cochrane Headline outcomes only
RR 0.74 [0.67, 0.81]
4 studies · 15397 participants
Low