Findings

What do systematic reviews say?

4 questions · 16 findings · 1 reviews · Headline outcomes only

No studies found 1 · 6.3%GRADE not reported 0 · 0%Very low 0 · 0%Low 1 · 6.3%Moderate 3 · 18.8%High 11 · 68.8%

Severe cases of rotavirus diarrhoea · children

Rotarix leads to lower severe cases of rotavirus diarrhoea compared with placebo (high certainty).

6 findings from 1 review

Vaccines for preventing rotavirus diarrhoea: vaccines in use 2021 · Cochrane Headline outcomes only
RR 0.07 [0.03, 0.18]
4 studies · 14976 participants
High
Vaccines for preventing rotavirus diarrhoea: vaccines in use 2021 · Cochrane Headline outcomes only
RR 0.42 [0.28, 0.61]
4 studies · 15822 participants
High
Vaccines for preventing rotavirus diarrhoea: vaccines in use 2021 · Cochrane Headline outcomes only
RR 0.65 [0.51, 0.83]
2 studies · 13768 participants
Moderate

Show 3 more findings

Vaccines for preventing rotavirus diarrhoea: vaccines in use 2021 · Cochrane Headline outcomes only
RR 0.1 [0.07, 0.14]
6 studies · 18145 participants
High
Vaccines for preventing rotavirus diarrhoea: vaccines in use 2021 · Cochrane Headline outcomes only
RR 0.21 [0.16, 0.29]
4 studies · 31671 participants
High
Vaccines for preventing rotavirus diarrhoea: vaccines in use 2021 · Cochrane Headline outcomes only
RR 0.23 [0.17, 0.29]
3 studies · 23834 participants
High

Severe cases of rotavirus diarrhoea · children

RotaTeq leads to lower severe cases of rotavirus diarrhoea compared with placebo (high certainty).

6 findings from 1 review

Vaccines for preventing rotavirus diarrhoea: vaccines in use 2021 · Cochrane Headline outcomes only
RR 0.03 [0.01, 0.11]
5 studies · 7688 participants
High
Vaccines for preventing rotavirus diarrhoea: vaccines in use 2021 · Cochrane Headline outcomes only
RR 0.04 [0.01, 0.11]
2 studies · 5442 participants
High
Vaccines for preventing rotavirus diarrhoea: vaccines in use 2021 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Show 3 more findings

Vaccines for preventing rotavirus diarrhoea: vaccines in use 2021 · Cochrane Headline outcomes only
RR 0.21 [0.11, 0.41]
1 study · 3863 participants
Low
Vaccines for preventing rotavirus diarrhoea: vaccines in use 2021 · Cochrane Headline outcomes only
RR 0.43 [0.29, 0.64]
2 studies · 6775 participants
High
Vaccines for preventing rotavirus diarrhoea: vaccines in use 2021 · Cochrane Headline outcomes only
RR 0.56 [0.41, 0.77]
2 studies · 6744 participants
High

Severe cases of rotavirus diarrhoea · children

Rotasiil leads to lower severe cases of rotavirus diarrhoea compared with placebo (high certainty).

2 findings from 1 review

Vaccines for preventing rotavirus diarrhoea: vaccines in use 2021 · Cochrane Headline outcomes only
RR 0.52 [0.33, 0.81]
2 studies · 11008 participants
High
Vaccines for preventing rotavirus diarrhoea: vaccines in use 2021 · Cochrane Headline outcomes only
RR 0.56 [0.42, 0.74]
2 studies · 11008 participants
High

Severe cases of rotavirus diarrhoea · children

Rotavac probably leads to lower severe cases of rotavirus diarrhoea compared with placebo (moderate certainty).

2 findings from 1 review

Vaccines for preventing rotavirus diarrhoea: vaccines in use 2021 · Cochrane Headline outcomes only
RR 0.43 [0.3, 0.6]
1 study · 6799 participants
Moderate
Vaccines for preventing rotavirus diarrhoea: vaccines in use 2021 · Cochrane Headline outcomes only
RR 0.46 [0.35, 0.6]
1 study · 6541 participants
Moderate