Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

9 questions · 9 findings · 2 reviews · Headline outcomes only

No studies found 1 · 11.1%GRADE not reported 0 · 0%Very low 5 · 55.6%Low 3 · 33.3%Moderate 0 · 0%High 0 · 0%

Plasma‐derived C1 esterase inhibitor vs placebo or active control

Serious adverse events (during · children or adults with Types I or II HAE

It is very uncertain whether plasma‐derived C1 esterase inhibitor changes serious adverse events (during compared with placebo or active control (very low certainty).

1 finding from 1 review

Recombinant human C1 esterase inhibitor vs placebo or active control

Serious adverse events (during · children or adults with Types I or II HAE

It is very uncertain whether recombinant human C1 esterase inhibitor changes serious adverse events (during compared with placebo or active control (very low certainty).

1 finding from 1 review

Intervention not reported

Serious adverse events during the trial period · all trials contributing results to the summary of findings table included people with mild disease (WHO scale 1 to 3)§

The intervention showed no clear difference in serious adverse events during the trial period (low certainty).

1 finding from 1 review

Intervention not reported

Serious adverse events during the trial period · people with moderate to severe disease (WHO scale 4–9); all trials contributing results to the summary of findings table investigated…

It is very uncertain whether the intervention changes serious adverse events during the trial period (very low certainty).

1 finding from 1 review