Findings

What do systematic reviews say?

3 questions · 3 findings · 1 reviews · Tobacco Addiction

No studies found 0 · 0%GRADE not reported 0 · 0%Very low 0 · 0%Low 2 · 66.7%Moderate 1 · 33.3%High 0 · 0%

Serious adverse events · people who smoke

Bupropion showed no clear difference in serious adverse events compared with placebo/no pharmacological treatment (moderate certainty).

1 finding from 1 review

Antidepressants for smoking cessation 2023 · Cochrane Headline outcomes only
RR 1.16 [0.9, 1.48]
23 studies · 10958 participants
Moderate

Serious adverse events · people who smoke

Bupropion plus varenicline showed no clear difference in serious adverse events compared with varenicline alone (low certainty).

1 finding from 1 review

Antidepressants for smoking cessation 2023 · Cochrane Headline outcomes only
RR 1.23 [0.63, 2.42]
5 studies · 1268 participants
Low

Serious adverse events · people who smoke

Bupropion plus nicotine replacement therapy (NRT) showed no clear difference in serious adverse events compared with NRT alone (low certainty).

1 finding from 1 review

Antidepressants for smoking cessation 2023 · Cochrane Headline outcomes only
RR 1.52 [0.26, 8.89]
4 studies · 657 participants
Low