evidencegaps
Findings

What do systematic reviews say?

Refine by population, intervention, comparison or outcome
More filters
Evidence found and GRADE certainty

26 questions · 26 findings · 21 reviews

Sort:Best matchNewestHighest certaintyDownload CSV
No studies found 4 · 15.4%GRADE not reported 3 · 11.5%Very low 7 · 26.9%Low 4 · 15.4%Moderate 8 · 30.8%High 0 · 0%

Low dose naldemedine vs higher dose

Serious adverse eventsg · people with cancer irrespective of whether receiving palliative care and with opioid‐induced bowel dysfunction

Low dose naldemedine showed no clear difference in serious adverse eventsg compared with higher doses (low certainty).

1 finding from 1 review

Lower blood pressure targets vs standard blood pressure targets

Total serious adverse events · cardiovascular disease with high blood pressure

Lower blood pressure targets showed no clear difference in total serious adverse events compared with standard blood pressure targets (low certainty).

1 finding from 1 review

SiT for maintenance/relief vs higher‐dose ICS/LABA + SABA

Patients with serious adverse events · Studies recruited adults and adolescents aged 12 and older with chronic asthma

SiT for maintenance/relief showed no clear difference in patients with serious adverse events compared with higher‐dose ICS/LABA + SABA (moderate certainty).

1 finding from 1 review

Intervention not reported

Serious adverse events during treatment · participants with alcoholic hepatitis at high risk of mortality and morbidity

It is very uncertain whether the intervention changes serious adverse events during treatment (very low certainty).

1 finding from 1 review

Intervention not reported

Participants with non‐serious adverse events: up to 3 months' · participants with alcoholic hepatitis at high risk of mortality and morbidity

It is very uncertain whether the intervention changes participants with non‐serious adverse events: up to 3 months' (very low certainty).

1 finding from 1 review

Comprehensive geriatric assessment (CGA) vs usual care

Serious adverse events (falls) Median · older people at risk of poor health outcomes

It is very uncertain whether comprehensive Geriatric Assessment changes serious adverse events (falls) Median compared with usual care (very low certainty).

1 finding from 1 review