Findings

What do systematic reviews say?

4 questions · 8 findings · 1 reviews · Headline outcomes only

No studies found 0 · 0%GRADE not reported 0 · 0%Very low 2 · 25%Low 6 · 75%Moderate 0 · 0%High 0 · 0%

Serious adverse events: intussusception · children

Rotarix showed no clear difference in serious adverse events: intussusception compared with placebo (low certainty).

3 findings from 1 review

Vaccines for preventing rotavirus diarrhoea: vaccines in use 2021 · Cochrane Headline outcomes only
RR 0.72 [0.39, 1.32]
6 studies · 75540 participants
Low
Vaccines for preventing rotavirus diarrhoea: vaccines in use 2021 · Cochrane Headline outcomes only
RR 1.49 [0.06, 36.63]
5 studies · 17068 participants
Low
Vaccines for preventing rotavirus diarrhoea: vaccines in use 2021 · Cochrane Headline outcomes only
RR 1.42 [0.52, 3.87]
10 studies · 20773 participants
Low

Serious adverse events: intussusception · children

RotaTeq showed no clear difference in serious adverse events: intussusception compared with placebo (low certainty).

3 findings from 1 review

Vaccines for preventing rotavirus diarrhoea: vaccines in use 2021 · Cochrane Headline outcomes only
RR 0.69 [0.35, 1.38]
9 studies · 73925 participants
Low
Vaccines for preventing rotavirus diarrhoea: vaccines in use 2021 · Cochrane Headline outcomes only
RR 5.01 [0.24, 104.29]
2 studies · 4082 participants
Very low
Vaccines for preventing rotavirus diarrhoea: vaccines in use 2021 · Cochrane Headline outcomes only
RR 0.33 [0.01, 8.16]
2 studies · 7488 participants
Low

Serious adverse events: intussusception · children

Rotasiil showed no clear difference in serious adverse events: intussusception compared with placebo (low certainty).

1 finding from 1 review

Vaccines for preventing rotavirus diarrhoea: vaccines in use 2021 · Cochrane Headline outcomes only
RR 0.98 [0.35, 2.74]
2 studies · 11586 participants
Low

Serious adverse events: intussusception · children

It is very uncertain whether rotavac changes serious adverse events: intussusception compared with placebo (very low certainty).

1 finding from 1 review

Vaccines for preventing rotavirus diarrhoea: vaccines in use 2021 · Cochrane Headline outcomes only
RR 1.33 [0.35, 5.02]
4 studies · 8582 participants
Very low