What do systematic reviews say?

Methotrexate vs placebo

Methotrexate showed no clear difference in serious adverse events compared with placebo (moderate certainty).

• Immunomodulatory treatment other than corticosteroids, immunoglobulin and plasma exchange for chronic inflammatory… 2017 · Cochrane Headline outcomes only
  RR 3.56 [0.39, 32.23]
  1 study · 59 participants
  Moderate