Findings

What do systematic reviews say?

3 questions · 3 findings · 3 reviews · Dental caries

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No studies found 0 · 0%GRADE not reported 0 · 0%Very low 2 · 66.7%Low 0 · 0%Moderate 0 · 0%High 1 · 33.3%

Fluoride mouthrinse (any fluoride agent, concentration, volume, frequency or technique; swished and expectorated, not swallowed) vs placebo or no treatment

Mucosal irritation / oral soft tissue allergic reaction (signs of sensitivity) · Children and adolescents aged 16 years or less

1 finding from 1 review

Fluoride mouthrinses for preventing dental caries in children and adolescents 2016 · Cochrane All outcomes
At least 1 year/school year
One trial (Rugg-Gunn 1973) reported incompletely on oral soft tissue irritation/signs of sensitivity (allergic reaction): "no cases of mucosal hypersensitivity after periodical examinations of every subject". 434…
1 study · 434 participants
Very low

Direct composite resin restoration vs Amalgam restoration

Harms (toxicity and postoperative sensitivity) · People with permanent or adult posterior teeth requiring restoration (parallel-group trials involved children aged 6 to 12 years)

1 finding from 1 review

Direct composite resin fillings versus amalgam fillings for permanent posterior teeth 2021 · Cochrane All outcomes
Follow-up: 2 weeks to 7 years
SoF (Harms, follow-up 2 weeks to 7 years): See comments; 3 studies; certainty very low (⊕⊝⊝⊝). Comments: data were reported for physical development, neurological and psychological effects, neurobehavioural and…
3 studies
Very low

Ion-releasing restorations (IRR): RMGIC, HVGIC, GIC, compomer/PMRC, giomer vs Composite resin (CR), including bulk-fill composite

Absence of sensibility (post-operative sensitivity) · Children receiving dental restorations (aged 4-11 years; primary teeth; Class I/II/V cavities)

No significant difference between IRR and CR in post-operative sensitivity (high certainty).

1 finding from 1 review

Clinical effectiveness of ion-releasing restorations compared to composite restorations in pediatric dental… 2025 All outcomes
1 to 2 years · Pediatric dentistry; primary molars/teeth (Class I, II, V cavities); trials from Turkey, Greece, Sweden, Brazil, and China
RR 1.02 [0.95, 1.11]
3 studies · 197 participants
High