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What do systematic reviews say?

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Evidence found and GRADE certainty

5 questions · 5 findings · 1 reviews · Headline outcomes only

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No studies found 2 · 40%GRADE not reported 0 · 0%Very low 1 · 20%Low 0 · 0%Moderate 2 · 40%High 0 · 0%

Intravenous midazolam vs intravenous diazepam

Seizure recurrence within 24 hours · Children with acute tonic‐clonic seizures

Summary of findings ‐ Intravenous midazolam showed no clear difference in seizure recurrence within 24 hours compared with intravenous diazepam (moderate certainty).

1 finding from 1 review

Intravenous midazolam vs intravenous lorazepam

Seizure recurrence within 24 hours · Children with acute tonic‐clonic seizures

Summary of findings ‐ Intravenous midazolam showed no clear difference in seizure recurrence within 24 hours compared with intravenous lorazepam (moderate certainty).

1 finding from 1 review

Summary of findings ‐ Intramuscular midazolam vs intravenous diazepam

Seizure recurrence within 24 hours: within one hour · Children with acute tonic‐clonic seizures

It is very uncertain whether summary of findings ‐ Intramuscular midazolam changes seizure recurrence within 24 hours: within one hour compared with intravenous diazepam (very low certainty).

1 finding from 1 review