What do systematic reviews say?

Summary of findings ‐ Intravenous lorazepam vs intravenous diazepam/intravenous phenytoin combination

• Drug management for acute tonic‐clonic convulsions including convulsive status epilepticus in children 2018 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 178 participants
  Moderate

Summary of findings ‐ Buccal midazolam vs rectal diazepam

The review found no eligible studies for this question.

• Drug management for acute tonic‐clonic convulsions including convulsive status epilepticus in children 2018 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Summary of findings ‐ Buccal midazolam vs intravenous diazepam

The review found no eligible studies for this question.

• Drug management for acute tonic‐clonic convulsions including convulsive status epilepticus in children 2018 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Summary of findings ‐ Intranasal midazolam vs intravenous diazepam

The review found no eligible studies for this question.

• Drug management for acute tonic‐clonic convulsions including convulsive status epilepticus in children 2018 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Summary of findings ‐ Intranasal midazolam vs rectal diazepam

The review found no eligible studies for this question.

• Drug management for acute tonic‐clonic convulsions including convulsive status epilepticus in children 2018 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Benzodiazepines (lorazepam) vs diazepam

Summary of findings ‐ Lorazepam showed no clear difference in seizure recurrence within 24 hours compared with diazepam (moderate certainty).

• Drug management for acute tonic‐clonic convulsions including convulsive status epilepticus in children 2018 · Cochrane Headline outcomes only
  RR 0.86 [0.61, 1.2]
  3 studies · 439 participants
  Moderate

Summary of findings ‐ Intramuscular midazolam vs rectal diazepam

• Drug management for acute tonic‐clonic convulsions including convulsive status epilepticus in children 2018 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 100 participants
  Moderate

Intravenous midazolam vs intravenous diazepam

Summary of findings ‐ Intravenous midazolam showed no clear difference in seizure recurrence within 24 hours compared with intravenous diazepam (moderate certainty).

• Drug management for acute tonic‐clonic convulsions including convulsive status epilepticus in children 2018 · Cochrane Headline outcomes only
  RR 0.5 [0.1, 2.58]
  1 study · 80 participants
  Moderate

Summary of findings ‐ Intramuscular midazolam vs intravenous diazepam

It is very uncertain whether summary of findings ‐ Intramuscular midazolam changes seizure recurrence within 24 hours: within one hour compared with intravenous diazepam (very low certainty).

• Drug management for acute tonic‐clonic convulsions including convulsive status epilepticus in children 2018 · Cochrane Headline outcomes only
  RR 0.85 [0.27, 2.62]
  1 study · 24 participants
  Very low