Findings

What do systematic reviews say?

3 questions · 3 findings · 1 reviews · Epilepsy

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No studies found 0 · 0%GRADE not reported 0 · 0%Very low 1 · 33.3%Low 1 · 33.3%Moderate 1 · 33.3%High 0 · 0%

Summary of findings ‐ Intravenous lorazepam vs intravenous diazepam/intravenous phenytoin combination

Seizure cessation: within 10 minutes · Children with acute tonic‐clonic seizures

Summary of findings ‐ Intravenous lorazepam showed no clear difference in seizure cessation: within 10 minutes compared with intravenous diazepam/intravenous phenytoin combination (moderate certainty).

1 finding from 1 review

Drug management for acute tonic‐clonic convulsions including convulsive status epilepticus in children 2018 · Cochrane Headline outcomes only
RR 1 [0.98, 1.02]
1 study · 178 participants
Moderate

Summary of findings ‐ Intranasal midazolam vs rectal diazepam

Seizure cessation: within 10 minutes · Children with acute tonic‐clonic seizures

Summary of findings ‐ Intranasal midazolam showed no clear difference in seizure cessation: within 10 minutes compared with rectal diazepam (low certainty).

1 finding from 1 review

Drug management for acute tonic‐clonic convulsions including convulsive status epilepticus in children 2018 · Cochrane Headline outcomes only
RR 1.47 [1, 2.16]
1 study · 45 participants
Low

Summary of findings ‐ Buccal midazolam vs rectal diazepam

Seizure cessation: within 5 minutes to 1 hour · Children with acute tonic‐clonic seizures

It is very uncertain whether summary of findings ‐ Buccal midazolam changes seizure cessation: within 5 minutes to 1 hour compared with rectal diazepam (very low certainty).

1 finding from 1 review

Drug management for acute tonic‐clonic convulsions including convulsive status epilepticus in children 2018 · Cochrane Headline outcomes only
RR 1.25 [1.13, 1.38]
4 studies · 648 participants
Very low