Findings

What do systematic reviews say?

2 questions · 3 findings · 1 reviews · Oral medicine and oral cancer

No studies found 0 · 0%GRADE not reported 2 · 66.7%Very low 1 · 33.3%Low 0 · 0%Moderate 0 · 0%High 0 · 0%

Salivary flow rate (unstimulated) · Patients receiving radiotherapy on its own or in addition to chemotherapy to the head and neck region

It is very uncertain whether amifostine changes salivary flow rate (mg/5 min, unstimulated) compared with no treatment/placebo (very low certainty).

2 findings from 1 review

Salivary flow rate · Patients receiving radiotherapy on its own or in addition to chemotherapy to the head and neck region

Amifostine led to higher salivary flow rate (incidence of > 0.1 g saliva/5 min, unstimulated) compared with no treatment/placebo; GRADE not reported.

1 finding from 1 review

Pharmacological interventions for preventing dry mouth and salivary gland dysfunction following radiotherapy 2017 · Cochrane All outcomes
12 months postRT
RR 1.45 [1.13, 1.86]
1 study · 175 participants
GRADE not reported