Findings

What do systematic reviews say?

1 questions · 1 findings · 1 reviews · Musculoskeletal

No studies found 0 · 0%GRADE not reported 0 · 0%Very low 0 · 0%Low 0 · 0%Moderate 0 · 0%High 1 · 100%

At least 50% reduction in pain · predominantly knee osteoarthritis

Antidepressant leads to higher responder rate: ≥ 50% reduction in 24‐hour mean pain compared with placebo (high certainty).

1 finding from 1 review

Antidepressants for hip and knee osteoarthritis 2022 · Cochrane Headline outcomes only
RR 1.55 [1.32, 1.82]
6 studies · 1904 participants
High