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What do systematic reviews say?

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Evidence found and GRADE certainty

3 questions · 4 findings · 1 reviews · Headline outcomes only

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No studies found 0 · 0%GRADE not reported 0 · 0%Very low 0 · 0%Low 3 · 75%Moderate 1 · 25%High 0 · 0%

Topical prophylaxis vs no topical prophylaxis

Respiratory infections · adults receiving mechanical ventilation for at least 48 hours

Topical prophylaxis may leads to lower respiratory tract infections ‐ topical prophylaxis versus no… compared with no topical prophylaxis (low certainty).

2 findings from 1 review

Topical prophylaxis vs no topical prophylaxis

Respiratory tract infections ‐ topical plus systemic prophylaxis versus systemic prophylaxis alone · adults receiving mechanical ventilation for at least 48 hours

Topical prophylaxis showed no clear difference in respiratory tract infections ‐ topical plus systemic prophylaxis… compared with no topical prophylaxis (low certainty).

1 finding from 1 review

Topical plus systemic prophylaxis vs placebo or no treatment

Respiratory infections · adults receiving mechanical ventilation for at least 48 hours

Topical plus systemic prophylaxis probably leads to lower respiratory tract infections compared with placebo or no treatment (moderate certainty).

1 finding from 1 review