Findings

What do systematic reviews say?

2 questions · 2 findings · 1 reviews · Cystic Fibrosis and Genetic Disorders

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No studies found 1 · 50%GRADE not reported 0 · 0%Very low 0 · 0%Low 1 · 50%Moderate 0 · 0%High 0 · 0%

Summary of findings ‐ withdrawal of penicillin prophylaxis vs continuation

Requirement of other courses of antibiotics · children with SCD who have been receiving prophylactic penicillin for at least two years

Summary of findings ‐ withdrawal of penicillin prophylaxis showed no clear difference in requirement of other courses of antibiotics compared with continuation (low certainty).

1 finding from 1 review

Prophylactic antibiotics for preventing pneumococcal infection in children with sickle cell disease 2021 · Cochrane Headline outcomes only
OR 0.94 [0.55, 1.61]
1 study · 400 participants
Low

Summary of findings ‐ initiation of penicillin prophylaxis vs placebo

Requirement of other courses of antibiotics · children with SCD

The review found no eligible studies for this question.

1 finding from 1 review

Prophylactic antibiotics for preventing pneumococcal infection in children with sickle cell disease 2021 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found