What do systematic reviews say?

Benzodiazepines (topical clonazepam) vs placebo

It is very uncertain whether benzodiazepines (topical clonazepam) changes relief of burning/discomfort (symptom relief; pain intensity) compared with placebo (very low certainty).

• Interventions for treating burning mouth syndrome 2016 · Cochrane All outcomes

  short-term (up to 3 months) · topical clonazepam
  MD -1.89 [-2.19, -1.59]
  2 studies · 111 participants
  Very low
• Interventions for treating burning mouth syndrome 2016 · Cochrane All outcomes

  long-term (>3 to 6 months) · topical clonazepam
  MD -1.39 [-1.96, -0.83]
  1 study · 66 participants
  Very low

Benzodiazepines (systemic clonazepam 0.5 mg/day) vs placebo

It is very uncertain whether benzodiazepines (systemic clonazepam 0.5 mg/day) changes relief of burning/discomfort (symptom relief; pain intensity) compared with placebo (very low certainty).

• Interventions for treating burning mouth syndrome 2016 · Cochrane All outcomes

  short-term (up to 3 months) · systemic clonazepam
  MD 0.00 [-1.86, 1.86]
  1 study · 20 participants
  Very low

Benzodiazepines (systemic clordemetildiazepam 1 mg/day) vs placebo

• Interventions for treating burning mouth syndrome 2016 · Cochrane All outcomes

  short-term (up to 3 months) · clordemetildiazepam
  Bogetto 1999 (clordemetildiazepam) included in the benzodiazepine comparison but data not presented (79% placebo-arm attrition).
  1 study
  GRADE not reported