What do systematic reviews say?

Fluoroquinolones vs macrolides

The review found no eligible studies for this question.

• Antibiotic therapy for Shigella dysentery 2010 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Fluoroquinolones vs beta‐lactams

It is very uncertain whether fluoroquinolones changes relapse ‐ All trials clinical criteria compared with beta‐lactams (very low certainty).

• Antibiotic therapy for Shigella dysentery 2010 · Cochrane Headline outcomes only
  RR 0.91 [0.11, 7.55]
  3 studies · 357 participants
  Very low

Ceftriaxone vs fluoroquinolones

It is very uncertain whether ceftriaxone changes relapse compared with fluoroquinolones (very low certainty).

• Treatment of enteric fever (typhoid and paratyphoid fever) with cephalosporins 2022 · Cochrane Headline outcomes only
  RR 0.95 [0.31, 2.92]
  3 studies · 297 participants
  Very low

Cefixime vs fluoroquinolones

Cefixime may leads to higher relapse compared with fluoroquinolones (low certainty).

• Treatment of enteric fever (typhoid and paratyphoid fever) with cephalosporins 2022 · Cochrane Headline outcomes only
  RR 4.45 [1.11, 17.84]
  2 studies · 220 participants
  Low

Fluoroquinolone substitution for isoniazid in a standard six month regimen vs standard regimen

• Fluoroquinolones for treating tuberculosis (presumed drug‐sensitive) 2013 · Cochrane Headline outcomes only
  no estimate extracted
  0 studies · 0 participants
  GRADE not reported

Fluoroquinolone plus standard regimen vs standard regimen

• Fluoroquinolones for treating tuberculosis (presumed drug‐sensitive) 2013 · Cochrane Headline outcomes only
  no estimate extracted
  0 studies · 0 participants
  GRADE not reported

Fluoroquinolone substitution for ethambutol in a standard six month regimen vs standard regimen

It is very uncertain whether fluoroquinolone substitution for ethambutol in a standard six month… changes relapse compared with standard regimen (very low certainty).

• Fluoroquinolones for treating tuberculosis (presumed drug‐sensitive) 2013 · Cochrane Headline outcomes only
  RR 0.71 [0.17, 3.06]
  1 study · 170 participants
  Very low

Cotrimoxazole vs fluoroquinolones

The review found no eligible studies for this question.

• Antibiotic therapy for Shigella dysentery 2010 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found