What do systematic reviews say?

Colchicine (0.5 mg per day for 3 months) vs prednisolone

Colchicine (0.5 mg per day for 3 months) showed no clear difference in recurrence during treatment period compared with prednisolone (5 mg per day for 3 months); GRADE not reported.

• Systemic interventions for recurrent aphthous stomatitis (mouth ulcers) 2012 · Cochrane All outcomes

  3 months
  RR 1.30 [0.98, 1.71]
  1 study · 34 participants
  GRADE not reported

Aciclovir (oral or intravenous) for treatment vs placebo

The review found no eligible studies for this question.

• Interventions for the prevention and treatment of herpes simplex virus in patients being treated for cancer 2009 · Cochrane All outcomes
  For the treatment comparison (aciclovir versus placebo), no data were available for recurrence of lesions, amount of analgesia, days of stay in hospital, cost of oral care or patient quality of life.
  0 studies
  No studies found

PET-CT following chemoradiotherapy (neck dissection only if no/incomplete response) vs Planned neck dissection before or after chemoradiotherapy

• Interventions for the treatment of oral cavity and oropharyngeal cancers: surgical treatment 2023 · Cochrane All outcomes
  Recurrence: outcome not reported in a usable way (Mehanna 2017: nodal recurrence 3 vs 1; distant metastases 21 vs 23).
  1 study
  GRADE not reported

Prophylactic aciclovir (oral or intravenous) vs placebo

The review found no eligible studies for this question.

• Interventions for the prevention and treatment of herpes simplex virus in patients being treated for cancer 2009 · Cochrane All outcomes
  Recurrence of lesions was a planned secondary outcome; no included trial reported data for this outcome in the prophylactic aciclovir versus placebo comparison.
  0 studies
  No studies found

PET-CT following chemoradiotherapy (neck dissection only if no/incomplete response) vs Planned neck dissection before or after chemoradiotherapy

PET-CT following chemoradiotherapy (neck dissection only if… showed no clear difference in locoregional recurrence compared with planned neck dissection before or after chemoradiotherapy (moderate certainty).

• Interventions for the treatment of oral cavity and oropharyngeal cancers: surgical treatment 2023 · Cochrane All outcomes

  3 years
  HR 1.00 [0.94, 1.06]
  1 study · 564 participants
  Moderate

Sentinel node biopsy (neck dissection only if biopsy positive) vs Elective neck dissection

• Interventions for the treatment of oral cavity and oropharyngeal cancers: surgical treatment 2023 · Cochrane All outcomes
  Recurrence: Garrel 2020 reported that the number of patients with recurrences in both arms was almost identical; unable to use the data (variable follow-up); 279 participants (1 RCT).
  1 study · 279 participants
  Very low

Elective neck dissection (at time of primary tumour resection) vs Therapeutic (delayed) neck dissection

Elective neck dissection (at time of primary tumour resection) probably leads to lower recurrence compared with therapeutic (delayed) neck dissection (moderate certainty).

• Interventions for the treatment of oral cavity and oropharyngeal cancers: surgical treatment 2023 · Cochrane All outcomes

  3 years
  RR 0.58 [0.48, 0.70]
  3 studies · 633 participants
  Moderate

Surgery plus radiotherapy vs Radiotherapy alone

The review found no eligible studies for this question.

• Interventions for the treatment of oral cavity and oropharyngeal cancers: surgical treatment 2023 · Cochrane All outcomes
  Recurrence: not reported.
  0 studies
  No studies found

Surgery plus radiotherapy vs Chemotherapy (chemoradiotherapy)

The review found no eligible studies for this question.

• Interventions for the treatment of oral cavity and oropharyngeal cancers: surgical treatment 2023 · Cochrane All outcomes

  oral cavity
  Recurrence: not reported for the oral cancer subgroup (Iyer 2015).
  0 studies
  No studies found

Surgery vs Radiotherapy alone

The review found no eligible studies for this question.

• Interventions for the treatment of oral cavity and oropharyngeal cancers: surgical treatment 2023 · Cochrane All outcomes
  Recurrence: not reported.
  0 studies
  No studies found

Superselective neck dissection vs Elective selective neck dissection

The review found no eligible studies for this question.

• Interventions for the treatment of oral cavity and oropharyngeal cancers: surgical treatment 2023 · Cochrane All outcomes
  Recurrence: outcome not reported in a usable way in either study.
  0 studies
  No studies found

Elective radical (comprehensive) neck dissection vs Elective selective neck dissection

It is very uncertain whether elective radical (comprehensive) neck dissection changes recurrence compared with elective selective neck dissection (very low certainty).

• Interventions for the treatment of oral cavity and oropharyngeal cancers: surgical treatment 2023 · Cochrane All outcomes

  5 years
  RR 1.21 [0.63, 2.33]
  1 study · 143 participants
  Very low

Supraomohyoid neck dissection vs Modified radical neck dissection

• Interventions for the treatment of oral cavity and oropharyngeal cancers: surgical treatment 2023 · Cochrane All outcomes
  Recurrence: reported but not usable (variable follow-up) (Guo 2014).
  1 study
  GRADE not reported

Primary surgical intervention (curettage, peripheral osteotomy, or resection) vs Primary non-surgical intervention (intralesional corticosteroids, subcutaneous calcitonin, interferon alpha, or imatinib)

The review found no eligible studies for this question.

• Interventions for central giant cell granuloma (CGCG) of the jaws 2009 · Cochrane All outcomes
  no estimate extracted
  0 studies
  No studies found

Occlusal splint vs Another occlusal splint with a different mechanism of action

The review found no eligible studies for this question.

• Occlusal interventions for managing temporomandibular disorders 2024 · Cochrane All outcomes
  Listed in Summary of findings 2 as 'Not reported'; this outcome was not reported by any included study for this comparison.
  0 studies
  No studies found

Occlusal splint vs acupuncture

The review found no eligible studies for this question.

• Occlusal interventions for managing temporomandibular disorders 2024 · Cochrane All outcomes
  Listed in Summary of findings 5 as 'Not reported'; this outcome was not reported by any included study for this comparison.
  0 studies
  No studies found

Occlusal splint vs Pharmacological therapy

The review found no eligible studies for this question.

• Occlusal interventions for managing temporomandibular disorders 2024 · Cochrane All outcomes
  Listed in Summary of findings 6 as 'Not reported'; this outcome was not reported by any included study for this comparison.
  0 studies
  No studies found

Occlusal splint vs Physical therapy (ultrasound, exercise, sensorimotor training, laser, TENS, manual therapy)

The review found no eligible studies for this question.

• Occlusal interventions for managing temporomandibular disorders 2024 · Cochrane All outcomes
  Listed in Summary of findings 3 as 'Not reported'; this outcome was not reported by any included study for this comparison.
  0 studies
  No studies found

Occlusal splint vs Behavioural therapy (counselling, CBT, relaxation, self-care management)

The review found no eligible studies for this question.

• Occlusal interventions for managing temporomandibular disorders 2024 · Cochrane All outcomes
  Listed in Summary of findings 4 as 'Not reported'; this outcome was not reported by any included study for this comparison.
  0 studies
  No studies found

Occlusal splint vs No treatment or placebo (non-occlusal or transparent-foil placebo splint)

The review found no eligible studies for this question.

• Occlusal interventions for managing temporomandibular disorders 2024 · Cochrane All outcomes
  Listed in Summary of findings 1 as 'Not reported'; this outcome was not reported by any included study for this comparison. Recurrence rate was not reported in any included study across the whole review.
  0 studies
  No studies found