Findings

What do systematic reviews say?

14 questions · 14 findings · 3 reviews · Headline outcomes only

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No studies found 8 · 57.1%GRADE not reported 0 · 0%Very low 2 · 14.3%Low 2 · 14.3%Moderate 2 · 14.3%High 0 · 0%

Subgroup analyses: early vs standard initiation of kidney replacement therapy (KRT)

Kidney recovery functionby KRT: continuous KRT · AKI

Subgroup analyses: early showed no clear difference in kidney recovery functionby KRT: continuous KRT compared with standard initiation of kidney replacement therapy (KRT) (moderate certainty).

1 finding from 1 review

Timing of kidney replacement therapy initiation for acute kidney injury 2022 · Cochrane Headline outcomes only
RR 1.42 [0.99, 2.03]
6 studies · 583 participants
Moderate

Subgroup analyses: early vs standard initiation of kidney replacement therapy (KRT)

Kidney recovery functionby KRT: continuous and intermittent KRT · AKI

Subgroup analyses: early showed no clear difference in kidney recovery functionby KRT: continuous and intermittent KRT compared with standard initiation of kidney replacement therapy (KRT) (moderate certainty).

1 finding from 1 review

Timing of kidney replacement therapy initiation for acute kidney injury 2022 · Cochrane Headline outcomes only
RR 0.96 [0.91, 1.02]
4 studies · 4134 participants
Moderate

Pre‐dilution vs post‐dilution (as defined by study investigators)

Recovery of kidney function · AKI patients receiving CKRT

The review found no eligible studies for this question.

1 finding from 1 review

Non‐pharmacological interventions for preventing clotting of extracorporeal circuits during continuous renal… 2021 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Higher blood flow vs standard blood flow

Recovery of kidney function · AKI patients receiving CKRT

The review found no eligible studies for this question.

1 finding from 1 review

Non‐pharmacological interventions for preventing clotting of extracorporeal circuits during continuous renal… 2021 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Long (> 20 cm) vs short (≤ 20 cm) catheter

Recovery of kidney function · AKI patients receiving CKRT

The review found no eligible studies for this question.

1 finding from 1 review

Non‐pharmacological interventions for preventing clotting of extracorporeal circuits during continuous renal… 2021 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Surface‐modified vs standard catheter

Recovery of kidney function · AKI patients receiving CKRT

Surface‐modified showed no clear difference in recovery of kidney function compared with standard double‐lumen catheter with identical geometry and flow design (low certainty).

1 finding from 1 review

Non‐pharmacological interventions for preventing clotting of extracorporeal circuits during continuous renal… 2021 · Cochrane Headline outcomes only
RR 0.91 [0.7, 1.2]
1 study · 236 participants
Low

Polyethylenimine‐treated membrane (AN69ST) vs other membranes

Recovery of kidney function · AKI patients receiving CKRT

The review found no eligible studies for this question.

1 finding from 1 review

Non‐pharmacological interventions for preventing clotting of extracorporeal circuits during continuous renal… 2021 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

CVVHD vs CVVH or CVVHDF

Recovery of kidney function · AKI patients receiving CKRT

It is very uncertain whether CVVHD changes recovery of kidney function compared with CVVH or CVVHDF (very low certainty).

1 finding from 1 review

Non‐pharmacological interventions for preventing clotting of extracorporeal circuits during continuous renal… 2021 · Cochrane Headline outcomes only
RR 0.91 [0.37, 2.21]
2 studies · 93 participants
Very low

Flat plate vs hollow fibre filter of the same membrane type

Recovery of kidney function · AKI patients receiving CKRT

The review found no eligible studies for this question.

1 finding from 1 review

Non‐pharmacological interventions for preventing clotting of extracorporeal circuits during continuous renal… 2021 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

More and shorter vs hollow fibre filter of the same membrane type

Recovery of kidney function · AKI patients receiving CKRT

The review found no eligible studies for this question.

1 finding from 1 review

Non‐pharmacological interventions for preventing clotting of extracorporeal circuits during continuous renal… 2021 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

CVVHDF vs standard CVVH

Recovery of kidney function · AKI patients receiving CKRT

It is very uncertain whether CVVHDF changes recovery of kidney function compared with CVVH (very low certainty).

1 finding from 1 review

Non‐pharmacological interventions for preventing clotting of extracorporeal circuits during continuous renal… 2021 · Cochrane Headline outcomes only
RR 1.1 [0.86, 1.41]
1 study · 96 participants
Very low

Unfractionated heparin vs low molecular weight heparin

Recovery of kidney function · CRRT

The review found no eligible studies for this question.

1 finding from 1 review

Pharmacological interventions for preventing clotting of extracorporeal circuits during continuous renal replacement… 2020 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Unfractionated heparin vs no pharmacological anticoagulation

Recovery of kidney function · CRRT

The review found no eligible studies for this question.

1 finding from 1 review

Pharmacological interventions for preventing clotting of extracorporeal circuits during continuous renal replacement… 2020 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Citrate vs unfractionated heparin

Recovery of kidney function · CRRT

Citrate showed no clear difference in recovery of kidney function compared with unfractionated heparin (low certainty).

1 finding from 1 review

Pharmacological interventions for preventing clotting of extracorporeal circuits during continuous renal replacement… 2020 · Cochrane Headline outcomes only
RR 1.04 [0.89, 1.21]
2 studies · 214 participants
Low