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What do systematic reviews say?

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Evidence found and GRADE certainty

2 questions · 2 findings · 1 reviews

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Mepolizumab 100 mg vs placebo

Rate of moderate or severe exacerbations Eosinophilic phenotype · patients with chronic obstructive pulmonary disease

Mepolizumab 100 mg leads to lower rate of moderate or severe exacerbations Eosinophilic phenotype compared with placebo (high certainty).

1 finding from 1 review

Mepolizumab 300 mg vs placebo

Rate of moderate or severe exacerbations Eosinophilic phenotype · patients with chronic obstructive pulmonary disease

Mepolizumab 300 mg showed no clear difference in rate of moderate or severe exacerbations Eosinophilic phenotype compared with placebo (moderate certainty).

1 finding from 1 review