What do systematic reviews say?

Analgesic (any: NSAID, paracetamol, local anaesthetic or opioid) vs placebo or control

• Pharmacological interventions for pain relief during orthodontic treatment 2017 · Cochrane All outcomes
  Reported narratively by 2 studies (Wang 2012: SF-36 and SAS - significant reduction in SF-36 bodily pain at 30 days vs baseline, no significant between-group differences; Minor 2009: STAI and PANAS - no significant…
  2 studies
  GRADE not reported

NSAID (systemic) vs paracetamol

The review found no eligible studies for this question.

• Pharmacological interventions for pain relief during orthodontic treatment 2017 · Cochrane All outcomes
  No studies in this comparison reported this outcome.
  0 studies
  No studies found

Topical NSAID (ketoprofen lysinate mouthwash, 160 mg) vs Topical NSAID (benzidamine hydrochloride mouthwash, 22.5 mg)

The review found no eligible studies for this question.

• Pharmacological interventions for pain relief during orthodontic treatment 2017 · Cochrane All outcomes
  The study did not report this outcome.
  0 studies
  No studies found

Ibuprofen taken pre-emptively (about 1 hour before treatment) vs Ibuprofen taken post-treatment

The review found no eligible studies for this question.

• Pharmacological interventions for pain relief during orthodontic treatment 2017 · Cochrane All outcomes
  No studies in this comparison reported this outcome.
  0 studies
  No studies found

Topical NSAID (ketoprofen chewing gum) vs Local anaesthetic (benzocaine chewing gum)

The review found no eligible studies for this question.

• Pharmacological interventions for pain relief during orthodontic treatment 2017 · Cochrane All outcomes
  The study did not report this outcome.
  0 studies
  No studies found