Findings

What do systematic reviews say?

15 questions · 15 findings · 4 reviews · Oral Health

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No studies found 13 · 86.7%GRADE not reported 2 · 13.3%Very low 0 · 0%Low 0 · 0%Moderate 0 · 0%High 0 · 0%

Adjunctive antimicrobial photodynamic therapy (aPDT) applied after submucosal instrumentation (SI) vs Submucosal instrumentation (SI) alone, or SI plus placebo/sham aPDT

Quality of life · Adults (> 18 years) with peri-implant mucositis, receiving active treatment

The review found no eligible studies for this question.

1 finding from 1 review

Adjunctive antimicrobial photodynamic therapy for treating periodontal and peri‐implant diseases 2024 · Cochrane All outcomes
Only one study reported evidence for adjunctive aPDT in people with peri-implant disease (Al Rifaiy 2022). Data were only available for two outcomes (PPD and BOP), both reported only at three months. No studies…
Studies not reported
No studies found

Adjunctive antimicrobial photodynamic therapy (aPDT) applied after subgingival instrumentation (SI) vs Subgingival instrumentation (SI) alone (hand or power-driven, or both), or SI plus placebo/sham aPDT

Quality of life · Adults (> 18 years) with a clinical diagnosis of periodontitis, receiving active (non-surgical anti-infective) treatment

The review found no eligible studies for this question.

1 finding from 1 review

Adjunctive antimicrobial photodynamic therapy for treating periodontal and peri‐implant diseases 2024 · Cochrane All outcomes
No studies reported data for this outcome.
Studies not reported
No studies found

Adjunctive antimicrobial photodynamic therapy (aPDT) applied after subgingival instrumentation (SI) vs Subgingival instrumentation (SI) alone (hand or power-driven, or both), or SI plus placebo/sham aPDT

Quality of life · Adults (> 18 years) with recurrent periodontitis, receiving supportive (maintenance) periodontal care

The review found no eligible studies for this question.

1 finding from 1 review

Adjunctive antimicrobial photodynamic therapy for treating periodontal and peri‐implant diseases 2024 · Cochrane All outcomes
No studies reported data for this outcome.
Studies not reported
No studies found

Antimicrobial lozenge vs placebo

Quality of life and other oral related symptoms · Patients receiving radiotherapy on its own or in addition to chemotherapy to the head and neck region

1 finding from 1 review

Pharmacological interventions for preventing dry mouth and salivary gland dysfunction following radiotherapy 2017 · Cochrane All outcomes
Over 6 months
Insufficient evidence of a difference for global quality of life, mouth pain RR 0.94 (95% CI 0.66 to 1.33), sore/burning mouth RR 0.95 (95% CI 0.68 to 1.35), throat pain RR 0.79 (95% CI 0.56 to 1.12) (Duncan 2005)
1 study
GRADE not reported

Periodontal treatment (subgingival instrumentation, with or without antimicrobials/surgery) vs usual care or no treatment

Quality of life indicators · People with diabetes mellitus (type 1 or type 2, mostly type 2) and periodontitis, at least 16 years of age

1 finding from 1 review

Treatment of periodontitis for glycaemic control in people with diabetes mellitus 2022 · Cochrane All outcomes
3-4 months
Three studies measured QoL. Vergnes 2018: overall GOHAI adjusted MD 7.0 (95% CI 2.4 to 11.6), 79 participants (better oral health-related QoL); no clear change in general SF-36 QoL. D'Aiuto 2018 ADDQoL better in…
3 studies
GRADE not reported

Doxycycline + SRP vs Metronidazole + SRP

Patient-reported quality of life changes · Adults with aggressive periodontitis

The review found no eligible studies for this question.

1 finding from 1 review

Adjunctive systemic antimicrobials for the non‐surgical treatment of periodontitis 2020 · Cochrane All outcomes
Long-term (≥ 1 year)
Included studies have not reported this outcome
Studies not reported
No studies found

Clindamycin + SRP vs Metronidazole + SRP

Patient-reported quality of life changes · Adults with aggressive periodontitis

The review found no eligible studies for this question.

1 finding from 1 review

Adjunctive systemic antimicrobials for the non‐surgical treatment of periodontitis 2020 · Cochrane All outcomes
Long-term (≥ 1 year)
Included studies have not reported this outcome
Studies not reported
No studies found

Clindamycin + SRP vs SRP

Patient-reported quality of life changes · Adults with aggressive periodontitis

The review found no eligible studies for this question.

1 finding from 1 review

Adjunctive systemic antimicrobials for the non‐surgical treatment of periodontitis 2020 · Cochrane All outcomes
Long-term (≥ 1 year)
Included studies have not reported this outcome
Studies not reported
No studies found

Tetracycline + SRP vs SRP

Patient-reported quality of life changes · Adults with aggressive periodontitis

The review found no eligible studies for this question.

1 finding from 1 review

Adjunctive systemic antimicrobials for the non‐surgical treatment of periodontitis 2020 · Cochrane All outcomes
Long-term (≥ 1 year)
Included studies have not reported this outcome
Studies not reported
No studies found

Doxycycline + SRP vs SRP

Patient-reported quality of life changes · Adults with aggressive periodontitis

The review found no eligible studies for this question.

1 finding from 1 review

Adjunctive systemic antimicrobials for the non‐surgical treatment of periodontitis 2020 · Cochrane All outcomes
Long-term (≥ 1 year)
Included studies have not reported this outcome
Studies not reported
No studies found

Amoxicillin + metronidazole + SRP vs SRP

Patient-reported quality of life changes · Adults with periodontitis (chronic and aggressive)

The review found no eligible studies for this question.

1 finding from 1 review

Adjunctive systemic antimicrobials for the non‐surgical treatment of periodontitis 2020 · Cochrane All outcomes
Long-term (≥ 1 year)
Included studies have not reported this outcome
Studies not reported
No studies found

Amoxicillin + clavulanate + SRP vs SRP

Patient-reported quality of life changes · Adults with chronic periodontitis

The review found no eligible studies for this question.

1 finding from 1 review

Adjunctive systemic antimicrobials for the non‐surgical treatment of periodontitis 2020 · Cochrane All outcomes
Long-term (≥ 1 year)
Included studies have not reported this outcome
Studies not reported
No studies found

Clindamycin + SRP vs Doxycycline + SRP

Patient-reported quality of life changes · Adults with aggressive periodontitis

The review found no eligible studies for this question.

1 finding from 1 review

Adjunctive systemic antimicrobials for the non‐surgical treatment of periodontitis 2020 · Cochrane All outcomes
Long-term (≥ 1 year)
Included studies have not reported this outcome
Studies not reported
No studies found

Azithromycin + SRP vs SRP

Patient-reported quality of life changes · Adults with periodontitis (chronic and aggressive)

The review found no eligible studies for this question.

1 finding from 1 review

Adjunctive systemic antimicrobials for the non‐surgical treatment of periodontitis 2020 · Cochrane All outcomes
Long-term (≥ 1 year)
Included studies have not reported this outcome
Studies not reported
No studies found

Metronidazole + SRP vs SRP

Patient-reported quality of life changes · Adults with periodontitis (chronic and aggressive)

The review found no eligible studies for this question.

1 finding from 1 review

Adjunctive systemic antimicrobials for the non‐surgical treatment of periodontitis 2020 · Cochrane All outcomes
Long-term (≥ 1 year)
Included studies have not reported this outcome
Studies not reported
No studies found