What do systematic reviews say?

Fixed‐dose combination aclidinium/formoterol vs aclidinium alone

Fixed‐dose combination aclidinium/formoterol showed no clear difference in quality of life: number of participants with clinically significant… compared with aclidinium alone (moderate certainty).

• Combined aclidinium bromide and long‐acting beta2‐agonist for chronic obstructive pulmonary disease (COPD) 2018 · Cochrane Headline outcomes only
  OR 1.17 [0.97, 1.41]
  2 studies · 2002 participants
  Moderate

Fixed‐dose combination aclidinium/formoterol vs formoterol

Fixed‐dose combination aclidinium/formoterol showed no clear difference in quality of life: number of participants with clinically significant… compared with formoterol (low certainty).

• Combined aclidinium bromide and long‐acting beta2‐agonist for chronic obstructive pulmonary disease (COPD) 2018 · Cochrane Headline outcomes only
  OR 1.15 [0.89, 1.5]
  1 study · 1000 participants
  Low

Benralizumab 10 mg vs placebo

• Anti‐IL‐5 therapies for chronic obstructive pulmonary disease 2020 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 680 participants
  Moderate

Benralizumab 30 mg vs placebo

• Anti‐IL‐5 therapies for chronic obstructive pulmonary disease 2020 · Cochrane Headline outcomes only
  no estimate extracted
  2 studies · 1333 participants
  Moderate

Benralizumab 100 mg vs placebo

• Anti‐IL‐5 therapies for chronic obstructive pulmonary disease 2020 · Cochrane Headline outcomes only
  no estimate extracted
  2 studies · 1351 participants
  High

Mepolizumab 300 mg vs placebo

• Anti‐IL‐5 therapies for chronic obstructive pulmonary disease 2020 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 451 participants
  Moderate

Mepolizumab 100 mg vs placebo

• Anti‐IL‐5 therapies for chronic obstructive pulmonary disease 2020 · Cochrane Headline outcomes only
  no estimate extracted
  2 studies · 911 participants
  Moderate

Mucolytic vs placebo

• Mucolytic agents versus placebo for chronic bronchitis or chronic obstructive pulmonary disease 2019 · Cochrane Headline outcomes only
  no estimate extracted
  7 studies · 2721 participants
  Moderate

Intervention not reported

The intervention probably leads to higher quality of life (dyspnoea) Measured on the CRQ, the output is a… (moderate certainty).

• Ambulatory oxygen for people with chronic obstructive pulmonary disease who are not hypoxaemic at rest 2014 · Cochrane Headline outcomes only
  MD 0.28 [0.1, 0.45]
  4 studies · 341 participants
  Moderate

Tiotropium vs placebo

Tiotropium showed no clear difference in quality of life (SGRQ) Scale 0 to 100, where 100 represents worst… compared with placebo (high certainty).

• Tiotropium versus placebo for chronic obstructive pulmonary disease 2014 · Cochrane Headline outcomes only
  no estimate extracted
  9 studies · 13034 participants
  High

Summary of findings (water exercise vs no exercise

• Water‐based exercise training for chronic obstructive pulmonary disease 2013 · Cochrane Headline outcomes only
  no estimate extracted
  19 participants
  Low

Pursed lip breathing vs no breathing exercises

• Breathing exercises for chronic obstructive pulmonary disease 2012 · Cochrane Headline outcomes only
  no estimate extracted
  2 studies · 60 participants
  Low

Summary of findings (water exercise vs land exercise)

• Water‐based exercise training for chronic obstructive pulmonary disease 2013 · Cochrane Headline outcomes only
  no estimate extracted
  60 participants
  Low

Ventilation feedback training plus exercise vs exercise

• Breathing exercises for chronic obstructive pulmonary disease 2012 · Cochrane Headline outcomes only
  no estimate extracted
  2 studies · 73 participants
  Moderate

SCS treatment for 7 or fewer days vs SCS treatment

• Different durations of corticosteroid therapy for exacerbations of chronic obstructive pulmonary disease 2018 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 271 participants
  Moderate

Intervention not reported

• Singing for adults with chronic obstructive pulmonary disease 2017 · Cochrane Headline outcomes only
  no estimate extracted
  2 studies · 52 participants
  Low

Intervention not reported

• Singing for adults with chronic obstructive pulmonary disease 2017 · Cochrane Headline outcomes only
  no estimate extracted
  2 studies · 52 participants
  Low

Intervention not reported

• Singing for adults with chronic obstructive pulmonary disease 2017 · Cochrane Headline outcomes only
  no estimate extracted
  2 studies · 58 participants
  Low