Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

841 questions · 854 findings · 331 reviews

No studies found 462 · 54.1%GRADE not reported 67 · 7.8%Very low 153 · 17.9%Low 116 · 13.6%Moderate 51 · 6%High 5 · 0.6%

Pilocarpine vs no treatment/placebo

Quality of life (McMaster HNRQ, 1-7 scale) · Patients receiving radiotherapy on its own or in addition to chemotherapy to the head and neck region

It is very uncertain whether pilocarpine changes quality of life (McMaster HNRQ, 1-7 scale) compared with no treatment/placebo (very low certainty).

1 finding from 1 review

Yoga vs an active intervention

Bothersomeness of symptoms at short term (6 weeks) Measured by the Overactive Bladder Symptom and Quality of Life‐Short Form (OABq‐SF) (lower = better) · women with urge‐predominant urinary incontinence
1 finding from 1 review

Occlusal splint vs Physical therapy (ultrasound, exercise, sensorimotor training, laser, TENS, manual therapy)

Participant satisfaction or quality of life · People with temporomandibular disorders (TMD)

Occlusal splint led to lower participant satisfaction or quality of life compared with physical therapy (ultrasound, exercise, sensorimotor training,…; GRADE not reported.

1 finding from 1 review

Occlusal splint vs acupuncture

Participant satisfaction or quality of life · People with temporomandibular disorders (TMD)

Occlusal splint showed no clear difference in participant satisfaction or quality of life compared with acupuncture; GRADE not reported.

1 finding from 1 review

Occlusal splint vs Another occlusal splint with a different mechanism of action

Participant satisfaction or quality of life · People with temporomandibular disorders (TMD)

Occlusal splint led to lower participant satisfaction or quality of life compared with another occlusal splint with a different mechanism of action; GRADE not reported.

1 finding from 1 review

Occlusal splint vs Behavioural therapy (counselling, CBT, relaxation, self-care management)

Participant satisfaction or quality of life · People with temporomandibular disorders (TMD)

Occlusal splint showed no clear difference in participant satisfaction or quality of life compared with behavioural therapy (counselling, CBT, relaxation, self-care…; GRADE not reported.

1 finding from 1 review

Combined HBO and perioperative antibiotics prior to dental implant therapy vs antibiotics alone

Adverse effects (including quality of life) · Adults with head and neck cancer undergoing curative or adjuvant radiotherapy (at risk of osteoradionecrosis of the jaws)
1 finding from 1 review

Analgesic (any: NSAID, paracetamol, local anaesthetic or opioid) vs placebo or control

Quality of life or participant satisfaction · People undergoing orthodontic treatment (any age; 9 to 34 years in included studies)
1 finding from 1 review