Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

22 questions · 22 findings · 10 reviews

No studies found 7 · 31.8%GRADE not reported 4 · 18.2%Very low 6 · 27.3%Low 3 · 13.6%Moderate 2 · 9.1%High 0 · 0%

Antidepressants vs placebo

Quality of life (EuroQol, scale −0.11 to 1.0 where a score of 1.0 indicates perfect health) between 0 and 14 weeks · predominantly knee osteoarthritis

Antidepressant probably leads to higher quality of life (EuroQol, scale −0.11 to 1.0 where a score of 1.0… compared with placebo (moderate certainty).

1 finding from 1 review