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What do systematic reviews say?

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Evidence found and GRADE certainty

5 questions · 5 findings · 1 reviews · Eyes and Vision

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No studies found 1 · 20%GRADE not reported 0 · 0%Very low 0 · 0%Low 0 · 0%Moderate 4 · 80%High 0 · 0%

Tocilizumab weekly vs placebo + 52‐week taper

Proportion of participants who did not need escape therapy (as defined by study investigators) · adults aged over 50 years with giant cell arteritis

Tocilizumab weekly probably leads to higher proportion of participants who did not need escape therapy (as… compared with placebo + 52‐week taper (moderate certainty).

1 finding from 1 review

Tocilizumab weekly vs placebo + 26‐week taper

Proportion of participants who did not need escape therapy (as defined by study investigators) · adults aged over 50 years with giant cell arteritis

Tocilizumab weekly probably leads to higher proportion of participants who did not need escape therapy (as… compared with placebo + 26‐week taper (moderate certainty).

1 finding from 1 review

Tocilizumab every other week vs placebo + 52‐week taper

Proportion of participants who did not need escape therapy (as defined by study investigators) · adults aged over 50 years with giant cell arteritis

Tocilizumab every other week probably leads to higher proportion of participants who did not need escape therapy (as… compared with placebo + 52‐week taper (moderate certainty).

1 finding from 1 review

Tocilizumab every other week vs placebo + 26‐week taper

Proportion of participants who did not need escape therapy (as defined by study investigators) · adults aged over 50 years with giant cell arteritis

Tocilizumab every other week showed no clear difference in proportion of participants who did not need escape therapy (as… compared with placebo + 26‐week taper (moderate certainty).

1 finding from 1 review

Tocilizumab every 4 weeks vs placebo

Proportion of participants who did not need escape therapy (as defined by study investigators) · adults aged over 50 years with giant cell arteritis

The review found no eligible studies for this question.

1 finding from 1 review