Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

5 questions · 5 findings · 1 reviews · Neonatal

No studies found 1 · 20%GRADE not reported 0 · 0%Very low 2 · 40%Low 1 · 20%Moderate 1 · 20%High 0 · 0%

Summary of findings table ‐ Phenytoin vs lorazepam

Proportion of infants who achieve seizure control after the first loading dose of ASM · neonates with clinically diagnosed seizures

It is very uncertain whether summary of findings table ‐ Phenytoin changes proportion of infants who achieve seizure control after the first… compared with lorazepam (very low certainty).

1 finding from 1 review

Phenobarbital vs levetiracetam

Proportion of infants who achieve seizure control after the first loading dose of ASM · neonates with EEG‐confirmed seizures

Summary of findings table ‐ Phenobarbital probably leads to higher proportion of infants who achieve seizure control after the first… compared with levetiracetam (moderate certainty).

1 finding from 1 review

Phenobarbital vs lorazepam

Proportion of infants who achieve seizure control after the first loading dose of ASM · neonates with clinically diagnosed seizures

It is very uncertain whether summary of findings table ‐ Phenobarbital changes proportion of infants who achieve seizure control after the first… compared with lorazepam (very low certainty).

1 finding from 1 review

Summary of findings table ‐ Phenobarbital + bumetanide vs phenobarbital

Proportion of infants who achieve seizure control after the first loading dose of ASM · neonates with EEG‐confirmed seizures

Summary of findings table ‐ Phenobarbital + bumetanide showed no clear difference in proportion of infants who achieve seizure control after the first… compared with phenobarbital alone (low certainty).

1 finding from 1 review