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Evidence found and GRADE certainty

6 questions · 6 findings · 1 reviews · Headline outcomes only

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No studies found 1 · 16.7%GRADE not reported 0 · 0%Very low 1 · 16.7%Low 1 · 16.7%Moderate 3 · 50%High 0 · 0%

Chloral hydrate oral (50 mg/kg + 50 mg/kg) vs hydroxyzine hydrochloride oral (1 mg/kg + 1 mg/kg)

Proportion of children who had sedation failure or inadequate level of sedation · children undergoing neurodiagnostic procedures

Chloral hydrate oral (50 mg/kg + 50 mg/kg) showed no clear difference in proportion of children who had sedation failure or inadequate level… compared with hydroxyzine hydrochloride oral (1 mg/kg + 1 mg/kg) (low certainty).

1 finding from 1 review

Chloral hydrate oral (70 mg/kg) vs promethazine

Proportion of children who had sedation failure or inadequate level of sedation · children undergoing neurodiagnostic procedures

Chloral hydrate oral (70 mg/kg) probably leads to lower proportion of children who had sedation failure or inadequate level… compared with promethazine oral (1 mg/kg) (moderate certainty).

1 finding from 1 review

Chloral hydrate oral (50 mg/kg or 100 mg/kg) vs dexmedetomidine oral (2 µg/kg or 3 µg/kg)

Proportion of children who had sedation failure or inadequate level of sedation · children undergoing neurodiagnostic procedures

Chloral hydrate oral (50 mg/kg or 100 mg/kg) showed no clear difference in proportion of children who had sedation failure or inadequate level… compared with dexmedetomidine oral (2 µg/kg or 3 µg/kg) (moderate certainty).

1 finding from 1 review

Chloral hydrate oral (60 mg/kg) vs music therapy

Proportion of children who had sedation failure or inadequate level of sedation · children undergoing neurodiagnostic procedures

It is very uncertain whether chloral hydrate oral (60 mg/kg) changes proportion of children who had sedation failure or inadequate level… compared with music therapy (very low certainty).

1 finding from 1 review

Chloral hydrate oral (50 mg/kg) vs sodium thiopental rectal (25 mg/kg)

Proportion of children who had sedation failure or inadequate level of sedation · children undergoing neurodiagnostic procedures

Chloral hydrate oral (50 mg/kg) showed no clear difference in proportion of children who had sedation failure or inadequate level… compared with sodium thiopental rectal (25 mg/kg) (moderate certainty).

1 finding from 1 review