Findings

What do systematic reviews say?

1 questions · 1 findings · 1 reviews · Colorectal

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No studies found 0 · 0%GRADE not reported 0 · 0%Very low 0 · 0%Low 0 · 0%Moderate 1 · 100%High 0 · 0%

IRI with fluoropyrimidines vs single agent IRI

Progression‐free survival (PSF) · patients with advanced and/or metastatic colorectal cancer

IRI with fluoropyrimidines probably leads to lower progression‐free survival (Disease progression) compared with single agent IRI (moderate certainty).

1 finding from 1 review

Irinotecan chemotherapy combined with fluoropyrimidines versus irinotecan alone for overall survival and… 2016 · Cochrane Headline outcomes only
HR 0.68 [0.53, 0.83]
3 studies · 600 participants
Moderate