Findings

What do systematic reviews say?

5 questions · 12 findings · 2 reviews · All outcomes

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No studies found 0 · 0%GRADE not reported 9 · 75%Very low 3 · 25%Low 0 · 0%Moderate 0 · 0%High 0 · 0%

Doxycycline + SRP vs SRP

Probing pocket depth · Adults with aggressive periodontitis

Doxycycline + SRP showed no clear difference in probing pocket depth compared with SRP; GRADE not reported.

3 findings from 1 review

Adjunctive systemic antimicrobials for the non‐surgical treatment of periodontitis 2020 · Cochrane All outcomes
Short-term (≤ 3 months)
MD 0.10 [-0.29, 0.50]
2 studies · 43 participants
GRADE not reported
Adjunctive systemic antimicrobials for the non‐surgical treatment of periodontitis 2020 · Cochrane All outcomes
Long-term (≥ 1 year)
MD -1.00 [-1.78, -0.22]
1 study · 22 participants
Very low
Adjunctive systemic antimicrobials for the non‐surgical treatment of periodontitis 2020 · Cochrane All outcomes
Intermediate-term (> 3 months to < 1 year)
MD -0.43 [-0.88, 0.01]
3 studies · 65 participants
GRADE not reported

Doxycycline + SRP vs Metronidazole + SRP

Probing pocket depth · Adults with aggressive periodontitis

Doxycycline + SRP showed no clear difference in probing pocket depth compared with metronidazole + SRP; GRADE not reported.

3 findings from 1 review

Adjunctive systemic antimicrobials for the non‐surgical treatment of periodontitis 2020 · Cochrane All outcomes
Intermediate-term (> 3 months to < 1 year)
MD 0.38 [0.00, 0.76]
3 studies · 75 participants
GRADE not reported
Adjunctive systemic antimicrobials for the non‐surgical treatment of periodontitis 2020 · Cochrane All outcomes
Long-term (≥ 1 year)
MD 1.00 [0.30, 1.70]
1 study · 27 participants
Very low
Adjunctive systemic antimicrobials for the non‐surgical treatment of periodontitis 2020 · Cochrane All outcomes
Short-term (≤ 3 months)
MD -0.16 [-0.56, 0.24]
2 studies · 49 participants
GRADE not reported

Doxycycline + SRP vs Amoxicillin + metronidazole + SRP

Probing pocket depth · Adults with aggressive periodontitis

Doxycycline + SRP showed no clear difference in probing pocket depth compared with amoxicillin + metronidazole + SRP; GRADE not reported.

2 findings from 1 review

Adjunctive systemic antimicrobials for the non‐surgical treatment of periodontitis 2020 · Cochrane All outcomes
Short-term (≤ 3 months)
MD 0.14 [-0.12, 0.40]
2 studies · 50 participants
GRADE not reported
Adjunctive systemic antimicrobials for the non‐surgical treatment of periodontitis 2020 · Cochrane All outcomes
Intermediate-term (> 3 months to < 1 year)
MD 0.23 [-0.41, 0.87]
1 study · 20 participants
GRADE not reported

Adjunctive local antibiotic (8.5% doxycycline hyclate, Atridox) added to manual debridement vs Manual debridement plus chlorhexidine irrigation/gel

Change in probing pocket depth (PPD) · People with at least one dental implant affected by perimplantitis

Adjunctive local antibiotic (8.5% doxycycline hyclate, Atridox)… led to higher change in probing pocket depth (PPD) compared with manual debridement with chlorhexidine (no antibiotic); GRADE not reported.

1 finding from 1 review

Interventions for replacing missing teeth: treatment of peri‐implantitis 2012 · Cochrane All outcomes
4 months (18 weeks)
MD 0.59 [0.39, 0.79]
1 study · 28 participants
GRADE not reported

Clindamycin + SRP vs Doxycycline + SRP

Probing pocket depth · Adults with aggressive periodontitis

It is very uncertain whether clindamycin + SRP changes probing pocket depth compared with doxycycline + SRP (very low certainty).

3 findings from 1 review

Adjunctive systemic antimicrobials for the non‐surgical treatment of periodontitis 2020 · Cochrane All outcomes
Long-term (≥ 1 year)
MD -0.80 [-1.58, -0.02]
1 study · 23 participants
Very low
Adjunctive systemic antimicrobials for the non‐surgical treatment of periodontitis 2020 · Cochrane All outcomes
Short-term (≤ 3 months)
MD 0.20 [-0.36, 0.76]
1 study · 23 participants
GRADE not reported
Adjunctive systemic antimicrobials for the non‐surgical treatment of periodontitis 2020 · Cochrane All outcomes
Intermediate-term (> 3 months to < 1 year)
MD -0.40 [-1.14, 0.34]
1 study · 23 participants
GRADE not reported