Findings

What do systematic reviews say?

5 questions · 5 findings · 1 reviews · Skin

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No studies found 1 · 20%GRADE not reported 0 · 0%Very low 0 · 0%Low 0 · 0%Moderate 2 · 40%High 2 · 40%

Corticosteroid creams/ointments: clobetasol propionate foam vs vehicle foam

Primary: investigator‐rated good/excellent control of symptoms · participants with moderate to severe hand eczema

Corticosteroid creams/ointments: clobetasol propionate foam showed no clear difference in primary: investigator‐rated good/excellent control of symptoms compared with vehicle foam (moderate certainty).

1 finding from 1 review

Interventions for hand eczema 2019 · Cochrane Headline outcomes only
RR 1.43 [0.86, 2.4]
1 study · 125 participants
Moderate

Tacrolimus 0.1% vs vehicle

Primary: investigator‐rated good/excellent control of symptoms · people with moderate to severe nickel sulphate‐induced allergic contact dermatitis based on clinical history (hand eczema) and proven by…

Topical calcineurin inhibitors: tacrolimus 0.1% ointment probably leads to higher primary: investigator‐rated good/excellent control of symptoms compared with vehicle (moderate certainty).

1 finding from 1 review

Interventions for hand eczema 2019 · Cochrane Headline outcomes only
RR 29 [1.9, 443.25]
1 study · 28 participants
Moderate

Oral retinoids: alitretinoin 30 mg vs placebo

Primary: investigator‐rated good/excellent control of symptoms · people with moderate to severe chronic hand eczema

Oral retinoids: alitretinoin 30 mg leads to higher primary: investigator‐rated good/excellent control of symptoms compared with placebo (high certainty).

1 finding from 1 review

Interventions for hand eczema 2019 · Cochrane Headline outcomes only
RR 2.75 [2.2, 3.43]
2 studies · 1210 participants
High

Oral retinoids: alitretinoin 10 mg vs placebo

Primary: investigator‐rated good/excellent control of symptoms · people with moderate to severe chronic hand eczema

Oral retinoids: alitretinoin 10 mg leads to higher primary: investigator‐rated good/excellent control of symptoms compared with placebo (high certainty).

1 finding from 1 review

Interventions for hand eczema 2019 · Cochrane Headline outcomes only
RR 1.58 [1.2, 2.07]
2 studies · 781 participants
High

Tacrolimus 0.1% vs mometasone furoate ointment

Primary: investigator‐rated good/excellent control of symptoms · people with moderate to severe chronic relapsing dyshidrotic eczema on hands

The review found no eligible studies for this question.

1 finding from 1 review

Interventions for hand eczema 2019 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found