Findings

What do systematic reviews say?

3 questions · 3 findings · 2 reviews · Endodontics and dental trauma

No studies found 0 · 0%GRADE not reported 2 · 66.7%Very low 0 · 0%Low 1 · 33.3%Moderate 0 · 0%High 0 · 0%

Postoperative pain · People requiring retreatment of periapical lesions (failed root canal therapy)

1 finding from 1 review

Endodontic procedures for retreatment of periapical lesions 2016 · Cochrane All outcomes
up to 7 days
Pain not assessed by VAS; reported significantly less in the PRF group at two time points only (2 and 6 hours after surgery).
1 study · 11 participants
GRADE not reported

Postoperative pain (VAS 0-100) - 1 day · People requiring retreatment of periapical lesions (failed root canal therapy)

Plasma rich in growth factors (PRGF) graft may leads to lower postoperative pain (VAS 0-100) - 1 day compared with no grafting (low certainty).

1 finding from 1 review

Endodontic procedures for retreatment of periapical lesions 2016 · Cochrane All outcomes
1 day
MD -51.60 [-63.43, -39.77]
1 study · 36 participants
Low

Postoperative pain and analgesic intake · Adults (18-45 y) with mature permanent molars, carious exposure and symptomatic irreversible pulpitis

Restricted partial pulpotomy causes less early postoperative pain and analgesic use than extended amputation (p<0.05; ungraded, single trial).

1 finding from 1 review

Partial pulpotomy for carious pulp exposure in adult mature permanent teeth: a systematic review and meta-analysis. 2025 All outcomes
Postoperative days 1-2 · Dental/endodontic clinical practice · Lateral extent of pulp amputation
Same RCT (Ramani 2024): restricted PP had significantly lower postoperative pain scores on days 1 and 2 (p<0.05) and required significantly less analgesic intake (p<0.05) than extended PP.
1 study · 96 participants
GRADE not reported