Findings

What do systematic reviews say?

2 questions · 2 findings · 2 reviews · Oral Health

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No studies found 0 · 0%GRADE not reported 1 · 50%Very low 0 · 0%Low 1 · 50%Moderate 0 · 0%High 0 · 0%

Cleft lip and/or palate (CL/P) vs Healthy controls without cleft

Plaque · Individuals assessed for periodontal health (mainly children and adolescents, age >2 years)

Persons with orofacial cleft have a higher plaque index than healthy controls (MD 0.29, 95% CI 0.24 to 0.34; low certainty).

1 finding from 1 review

Oral health in patients with cleft lip and palate: a systematic literature review and meta-analysis of periodontal and… 2025 All outcomes
Clinical dental examination; various countries (e.g., Brazil, India, China, Thailand, USA)
MD 0.29 [0.24, 0.34]
6 studies · 1618 participants
Low

Anorexia nervosa (as exposure; diagnosed by DSM-III/III-R/IV/V) vs Healthy controls

Plaque · Patients with anorexia nervosa aged >=12 years (mean age ~18.4; entirely female in reported data), general community-dwelling population

Anorexia nervosa patients tended to have higher plaque accumulation than healthy controls (significant in 2 of 3 studies), but results were not pooled or graded (ungraded).

1 finding from 1 review

The influence of anorexia nervosa on oral health and related parameters potentially relevant to orthodontic treatment:… 2025 All outcomes
Clinical dental/oral examination; case-control studies and controlled clinical trials in Europe (mainly Poland, Italy, France, Germany), Australia and the USA
In 2 of 3 studies anorexic patients had significantly higher plaque accumulation than controls (Pallier 78.8% vs 53.0%, p<0.01; Paszynska 43.8% vs 13.7%, p<0.001; Milosevic 84% vs 72%, NS); not meta-analyzed
3 studies · 394 participants
GRADE not reported