Findings

What do systematic reviews say?

2 questions · 2 findings · 2 reviews · Musculoskeletal

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No studies found 0 · 0%GRADE not reported 0 · 0%Very low 0 · 0%Low 0 · 0%Moderate 0 · 0%High 2 · 100%

Paracetamol vs placebo

Physical function · Patients with osteoarthritis of the knee or hip

Paracetamol showed no clear difference in physical function (WOMAC function 0–100) compared with placebo (high certainty).

1 finding from 1 review

Paracetamol versus placebo for knee and hip osteoarthritis 2019 · Cochrane Headline outcomes only
no estimate extracted
7 studies · 2354 participants
High

Antidepressants vs placebo

Physical function · predominantly knee osteoarthritis

Antidepressant showed no clear difference in mean change in physical function from baseline (0–100 WOMAC Total… compared with placebo (high certainty).

1 finding from 1 review

Antidepressants for hip and knee osteoarthritis 2022 · Cochrane Headline outcomes only
no estimate extracted
6 studies · 1909 participants
High