What do systematic reviews say?

Three doses HPV vaccine vs control

Three doses HPV vaccine showed no clear difference in penile or anal intraepithelial neoplasia at up to 3‐year compared with control (low certainty).

• Comparison of different human papillomavirus (HPV) vaccine types and dose schedules for prevention of HPV‐related… 2019 · Cochrane Headline outcomes only
  Rate ratio 0.17 [0.01, 3.27]
  1 study · 2805 participants
  Low