What do systematic reviews say?

Oxygenated glycerol triester (OGT) spray vs Saliveeze (aqueous electrolyte) spray

Oxygenated glycerol triester (OGT) spray showed no clear difference in patient satisfaction compared with saliveeze (aqueous electrolyte) spray; GRADE not reported.

• Interventions for the management of dry mouth: topical therapies 2011 · Cochrane All outcomes
  Mouly 2007b: patient satisfaction measured by VAS for global acceptability (Analysis 3.4); no significant difference between treatments for overall oral condition. Satisfaction for taste favoured OGT (mean VAS…
  1 study
  GRADE not reported

CMC spray / HCC spray / HCC gel vs Liquid margarine (and between each other)

• Interventions for the management of dry mouth: topical therapies 2011 · Cochrane All outcomes
  HCC gel rated better than margarine for convenience, perceived value, minutes of relief and overall rating; no other significant between-group differences.
  1 study · 28 participants
  GRADE not reported

Intraoral device releasing Biotene Oral Balance gel vs Manually administered bolus of the same gel

Intraoral device releasing Biotene Oral Balance gel showed no clear difference in patient satisfaction compared with manually administered bolus of the same gel; GRADE not reported.

• Interventions for the management of dry mouth: topical therapies 2011 · Cochrane All outcomes
  Patient satisfaction scores favoured the gel bolus over the intraoral device (Analysis 3.4).
  1 study · 22 participants
  GRADE not reported

Electrostimulation (device) vs Placebo (sham/placebo device)

The review found no eligible studies for this question.

• Interventions for the management of dry mouth: non‐pharmacological interventions 2013 · Cochrane All outcomes
  no estimate extracted
  0 studies
  No studies found

Acupuncture vs sham

The review found no eligible studies for this question.

• Interventions for the management of dry mouth: non‐pharmacological interventions 2013 · Cochrane All outcomes
  no estimate extracted
  0 studies
  No studies found

Toothbrushing + tongue cleaning with a tooth-and-tongue gel (amine/stannous fluoride + zinc lactate) vs Toothbrushing with reference toothpaste (with or without tongue cleaning)

• Interventions for managing halitosis 2019 · Cochrane All outcomes
  Wilhelm 2012 (3-arm cross-over trial) compared toothbrushing with a reference toothpaste, with reference toothpaste plus tongue cleaning, and toothbrushing plus tongue cleaning with a tooth-and-tongue gel (OLT, VSC,…
  1 study
  GRADE not reported

Mucin spray (Saliva Orthana) vs Placebo spray (base without mucin)

Mucin spray (Saliva Orthana) led to lower patient satisfaction / desire to continue treatment compared with placebo spray (base without mucin); GRADE not reported.

• Interventions for the management of dry mouth: topical therapies 2011 · Cochrane All outcomes
  Sweeney 1997: majority in both groups wished to continue the allocated spray, no significant difference (Analysis 1.3). Duxbury 1989: 14/30 (46.6%) and 15/30 (50%) wished to continue Saliva Orthana and the spray base…
  2 studies
  GRADE not reported

Systemic oral acyclovir vs placebo or no treatment

• Acyclovir for treating primary herpetic gingivostomatitis 2008 · Cochrane All outcomes
  Amir 1997b: no data available. Ducoulombier 1988: tolerance and acceptability of the drug was described as satisfactory, but it was unclear how this was assessed by the trialists.
  1 study
  GRADE not reported