Findings

What do systematic reviews say?

2 questions · 2 findings · 1 reviews

No studies found 0 · 0%GRADE not reported 0 · 0%Very low 0 · 0%Low 1 · 50%Moderate 1 · 50%High 0 · 0%

Participants with severe withdrawal · People undergoing managed opioid withdrawal

Alpha2‐adrenergic agonist showed no clear difference in participants with severe withdrawal compared with methadone (low certainty).

1 finding from 1 review

Alpha₂‐adrenergic agonists for the management of opioid withdrawal 2016 · Cochrane Headline outcomes only
RR 1.18 [0.81, 1.73]
5 studies · 340 participants
Low

Participants with severe withdrawal · People undergoing managed opioid withdrawal

Alpha2‐adrenergic agonist probably leads to lower participants with severe withdrawal compared with placebo (moderate certainty).

1 finding from 1 review

Alpha₂‐adrenergic agonists for the management of opioid withdrawal 2016 · Cochrane Headline outcomes only
RR 0.32 [0.18, 0.57]
3 studies · 148 participants
Moderate