What do systematic reviews say?

Paroxetine vs reboxetine

Paroxetine showed no clear difference in participants with at least some Side Effects compared with reboxetine (moderate certainty).

• Paroxetine versus other anti‐depressive agents for depression 2014 · Cochrane Headline outcomes only
  OR 1.08 [0.74, 1.58]
  3 studies · 1375 participants
  Moderate

Paroxetine vs sertraline

• Paroxetine versus other anti‐depressive agents for depression 2014 · Cochrane Headline outcomes only
  no estimate extracted
  0 studies · 0 participants
  GRADE not reported

Paroxetine vs tianeptine

Paroxetine showed no clear difference in participants with at least some Side Effects compared with tianeptine (moderate certainty).

• Paroxetine versus other anti‐depressive agents for depression 2014 · Cochrane Headline outcomes only
  OR 1.26 [0.89, 1.78]
  2 studies · 604 participants
  Moderate

Paroxetine vs trazodone

Paroxetine showed no clear difference in participants with at least some Side Effects compared with trazodone (moderate certainty).

• Paroxetine versus other anti‐depressive agents for depression 2014 · Cochrane Headline outcomes only
  OR 0.68 [0.3, 1.55]
  1 study · 108 participants
  Moderate

Paroxetine vs venlafaxine

Paroxetine showed no clear difference in participants with at least some Side Effects compared with venlafaxine (moderate certainty).

• Paroxetine versus other anti‐depressive agents for depression 2014 · Cochrane Headline outcomes only
  OR 1.01 [0.52, 1.95]
  2 studies · 200 participants
  Moderate

Paroxetine vs agomelatine

Paroxetine showed no clear difference in participants with at least some Side Effects compared with agomelatine (moderate certainty).

• Paroxetine versus other anti‐depressive agents for depression 2014 · Cochrane Headline outcomes only
  OR 1.6 [0.99, 2.59]
  1 study · 284 participants
  Moderate

Paroxetine vs AMISULPRIDE

Paroxetine showed no clear difference in participants with at least some Side Effects compared with amisulpride (moderate certainty).

• Paroxetine versus other anti‐depressive agents for depression 2014 · Cochrane Headline outcomes only
  OR 1.49 [0.89, 2.5]
  1 study · 277 participants
  Moderate

Paroxetine vs aprepitant

• Paroxetine versus other anti‐depressive agents for depression 2014 · Cochrane Headline outcomes only
  no estimate extracted
  0 studies · 0 participants
  GRADE not reported

Paroxetine vs bupropion

Paroxetine showed no clear difference in participants with at least some Side Effects compared with bupropion (moderate certainty).

• Paroxetine versus other anti‐depressive agents for depression 2014 · Cochrane Headline outcomes only
  OR 1.6 [0.43, 5.92]
  1 study · 140 participants
  Moderate

Paroxetine vs citalopram

Paroxetine showed no clear difference in participants with at least some Side Effects compared with citalopram (moderate certainty).

• Paroxetine versus other anti‐depressive agents for depression 2014 · Cochrane Headline outcomes only
  OR 0.74 [0.46, 1.21]
  1 study · 406 participants
  Moderate

Paroxetine vs duloxetine

Paroxetine showed no clear difference in participants with at least some Side Effects compared with duloxetine (moderate certainty).

• Paroxetine versus other anti‐depressive agents for depression 2014 · Cochrane Headline outcomes only
  OR 0.81 [0.64, 1.01]
  6 studies · 1870 participants
  Moderate

Paroxetine vs escitalopram

Paroxetine showed no clear difference in participants with at least some Side Effects compared with escitalopram (moderate certainty).

• Paroxetine versus other anti‐depressive agents for depression 2014 · Cochrane Headline outcomes only
  OR 1.28 [0.86, 1.91]
  1 study · 454 participants
  Moderate

Paroxetine vs fluoxetine

Paroxetine showed no clear difference in participants with at least some Side Effects compared with fluoxetine (moderate certainty).

• Paroxetine versus other anti‐depressive agents for depression 2014 · Cochrane Headline outcomes only
  OR 0.94 [0.69, 1.28]
  9 studies · 2255 participants
  Moderate

Paroxetine vs older ADs

Paroxetine probably leads to lower participants with at least some Side Effects compared with older ADs (moderate certainty).

• Paroxetine versus other anti‐depressive agents for depression 2014 · Cochrane Headline outcomes only
  OR 0.64 [0.54, 0.77]
  42 studies · 6132 participants
  Moderate

Paroxetine vs fluvoxamine

Paroxetine showed no clear difference in participants with at least some Side Effects compared with fluvoxamine (moderate certainty).

• Paroxetine versus other anti‐depressive agents for depression 2014 · Cochrane Headline outcomes only
  OR 1.12 [0.42, 2.97]
  3 studies · 261 participants
  Moderate

Paroxetine vs hypericum

Paroxetine probably leads to higher participants with at least some Side Effects compared with hypericum (moderate certainty).

• Paroxetine versus other anti‐depressive agents for depression 2014 · Cochrane Headline outcomes only
  OR 2.6 [1.51, 4.46]
  1 study · 251 participants
  Moderate

Paroxetine vs milnacipran

Paroxetine showed no clear difference in participants with at least some Side Effects compared with milnacipran (moderate certainty).

• Paroxetine versus other anti‐depressive agents for depression 2014 · Cochrane Headline outcomes only
  OR 0.69 [0.41, 1.15]
  1 study · 302 participants
  Moderate

Paroxetine vs mirtazapine

Paroxetine showed no clear difference in participants with at least some Side Effects compared with mirtazapine (moderate certainty).

• Paroxetine versus other anti‐depressive agents for depression 2014 · Cochrane Headline outcomes only
  OR 1.07 [0.76, 1.5]
  3 studies · 726 participants
  Moderate

Paroxetine vs nefazodone

Paroxetine showed no clear difference in participants with at least some Side Effects compared with nefazodone (moderate certainty).

• Paroxetine versus other anti‐depressive agents for depression 2014 · Cochrane Headline outcomes only
  OR 0.69 [0.34, 1.4]
  1 study · 206 participants
  Moderate