Findings

What do systematic reviews say?

5 questions · 5 findings · 2 reviews

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No studies found 3 · 60%GRADE not reported 0 · 0%Very low 1 · 20%Low 1 · 20%Moderate 0 · 0%High 0 · 0%

Selective serotonin reuptake inhibitors vs placebo

Participants with at least some Side Effects · cannabis dependence

It is very uncertain whether selective serotonin reuptake inhibitor antidepressant changes participants experiencing adverse effects compared with placebo (very low certainty).

1 finding from 1 review

Pharmacotherapies for cannabis dependence 2019 · Cochrane Headline outcomes only
RR 0.76 [0.57, 1.02]
1 study · 76 participants
Very low

S‐adenosyl methionine as monotherapy vs tricyclic antidepressants (TCAs)

Acceptability. Participants experiencing troublesome adverse effects of any nature · depression in adults

S‐adenosyl methionine as monotherapy may leads to lower acceptability. Participants experiencing troublesome adverse effects… compared with tricyclic antidepressant agent (low certainty).

1 finding from 1 review

S‐adenosyl methionine (SAMe) for depression in adults 2016 · Cochrane Headline outcomes only
RR 0.68 [0.52, 0.88]
3 studies · 604 participants
Low

S‐adenosyl methionine as monotherapy vs SSRI

Acceptability. Participants experiencing troublesome adverse effects of any nature · depression in adults

The review found no eligible studies for this question.

1 finding from 1 review

S‐adenosyl methionine (SAMe) for depression in adults 2016 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

S‐adenosyl methionine as adjunctive treatment vs placebo

Acceptability. Participants experiencing troublesome adverse effects of any nature · depression in adults

The review found no eligible studies for this question.

1 finding from 1 review

S‐adenosyl methionine (SAMe) for depression in adults 2016 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

S‐adenosyl methionine as monotherapy vs placebo

Acceptability. Participants experiencing troublesome adverse effects of any nature · depression in adults

The review found no eligible studies for this question.

1 finding from 1 review

S‐adenosyl methionine (SAMe) for depression in adults 2016 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found