Findings

What do systematic reviews say?

3 questions · 3 findings · 1 reviews · Drugs and Alcohol

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No studies found 0 · 0%GRADE not reported 0 · 0%Very low 0 · 0%Low 2 · 66.7%Moderate 1 · 33.3%High 0 · 0%

Mixed action antidepressant vs placebo

Abstinence · cannabis dependence

Mixed action antidepressant showed no clear difference in participants abstinent at end of treatment compared with placebo (low certainty).

1 finding from 1 review

Pharmacotherapies for cannabis dependence 2019 · Cochrane Headline outcomes only
RR 0.82 [0.12, 5.41]
2 studies · 179 participants
Low

Δ9‐Tetrahydrocannabinol preparation vs placebo

Abstinence · cannabis dependence

Δ9‐Tetrahydrocannabinol preparation showed no clear difference in participants abstinent at end of treatment compared with placebo (moderate certainty).

1 finding from 1 review

Pharmacotherapies for cannabis dependence 2019 · Cochrane Headline outcomes only
RR 0.98 [0.64, 1.52]
3 studies · 305 participants
Moderate

Selective serotonin reuptake inhibitors vs placebo

Abstinence · cannabis dependence

Selective serotonin reuptake inhibitor antidepressant showed no clear difference in participants abstinent at end of treatment compared with placebo (low certainty).

1 finding from 1 review

Pharmacotherapies for cannabis dependence 2019 · Cochrane Headline outcomes only
RR 1.73 [0.61, 4.89]
2 studies · 128 participants
Low