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What do systematic reviews say?

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Evidence found and GRADE certainty

2 questions · 2 findings · 1 reviews

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Topical clonidine (TC) vs placebo

Participant‐reported pain relief of 50% or greater · adults with painful diabetic neuropathy

Topical clonidine (TC) showed no clear difference in participant‐reported pain relief of 50% or greater during longest compared with placebo (low certainty).

1 finding from 1 review

Topical clonidine (TC) vs active comparators

Participant‐reported pain relief of 50% or greater · adults with painful diabetic neuropathy

Topical clonidine (TC) showed no clear difference in participant‐reported pain relief of 50% or greater during longest compared with active comparator (low certainty).

1 finding from 1 review